Evidence map›Paper›PMID 29374340›Full record

ArticleLifetime data analysis2018

Illness-death model: statistical perspective and differential equations.

Ralph Brinks, Annika Hoyer

Abstract read
PubMed Publisher
In one paragraph

Article in Lifetime data analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The global burden of inflammatory bowel disease: from 2025 to 2045.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ralph BrinksHiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany. ralph.brinks@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0003-0961-6592
Annika HoyerInstitute for Biometry and Epidemiology, German Diabetes Center, Duesseldorf, Germany.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related DementiasP01AG005842 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI KOSALI ILAYPERUMA SIMON · 1986 to 2026
$56.5M
WEALTH DISPARITIES AMONG MATURE AND OLDER ADULTSP01AG008291 · NIA · RAND CORPORATION · PI HURD, MICHAEL D · 1989 to 2018
$19.4M
RAND CENTER FOR THE STUDY OF AGINGP30AG012815 · NIA · RAND CORPORATION · PI HURD, MICHAEL D · 1999 to 2020
$13.7M
DEVELOPING AN ISRAELI VERSION OF THE HRS/SHARE PROJECTR21AG025169 · NIA · HEBREW UNIVERSITY OF JERUSALEM · PI LITWIN, HOWARD · 2004 to 2006
$297k
NIA NIH HHS P01 AG005842NIA NIH HHS P01 AG008291NIA NIH HHS P30 AG012815NIA NIH HHS R21 AG025169NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

The aim of this work is to relate the theory of stochastic processes with the differential equations associated with multistate (compartment) models. We show that the Kolmogorov Forward Differential Equations can be used to derive a relation between the prevalence and the transition rates in the illness-death model. Then, we prove mathematical well-definedness and epidemiological meaningfulness of the prevalence of the disease. As an application, we derive the incidence of diabetes from a series of cross-sections.

Indexed as

AlgorithmsChronic DiseaseDeathModels, StatisticalSurvival AnalysisAgedAged, 80 and overDiabetes MellitusGermanyHumansIncidenceMaleMiddle AgedPrevalenceStochastic ProcessesTime FactorsFix-Neyman competing risks modelIllness-death modelIncidenceKolmogorov Differential EquationsMarkov processesMultistate modelsNon-parametric estimation of transition ratesPrevalence

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.