SynthesisThe journal of headache and pain2018
Pressure pain thresholds over the cranio-cervical region in headache: a systematic review and meta-analysis.
Synthesis in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07627542 (An Investigation of the Effect of Smartphone Usage Levels on Cervical Posture, Tongue Pressure, Balance, and Neck Disability in Individuals With Rheumatoid Arthritis and Ankylosing Spondylitis), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation of the Effect of Smartphone Usage Levels on Cervical Posture, Tongue Pressure, Balance, and Neck Disability in Individuals With Rheumatoid Arthritis and Ankylosing Spondylitis
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Acupoint Sensitivity in Health and Disease: A Systematic Review.Journal of integrative and complementary medicine · 2024Pooled it
- Effects of diacutaneous fibrolysis in patients with tension-type headache: A randomized controlled trial.PloS one · 2023Trial
- Comparison of Early Effectiveness of Three Different Intervention Methods in Patients with Chronic Orofacial Pain: A Randomized, Controlled Clinical Trial.Pain research & management · 2019Trial
- Pressure Pain Thresholds Across Nerve-Related and Muscular Sites in Frequent Episodic Tension-Type Headache: An Exploratory Case-Control Study.Journal of clinical medicine · 2026Article
- Regional and Extraregional Pressure Pain Threshold Patterns in Tension-Type Headache and Low Back Pain: A Cross-Sectional Comparative Study.Journal of clinical medicine · 2026Article
- Pressure Pain Threshold Cut-Off Points at Trigeminal and Extra-Trigeminal Nervous and Musculoskeletal Structures to Discriminate Patients with Migraine from Episodic Tension-Type Headache: A Diagnostic Accuracy Study.Diagnostics (Basel, Switzerland) · 2026Article
- Exploring Pain Phenotyping in Cervicogenic Headache Management.Current pain and headache reports · 2025Review
- Biological Markers of Brain Network Connectivity and Pain Sensitivity Distinguish Low Coping from High Coping Veterans with Persistent Post-Traumatic Headache.Journal of neurotrauma · 2025Observational
- Jaw muscle and joint psychophysics-relevance for clinical orofacial pain practice and research. A narrative review.Journal of oral & facial pain and headache · 2025Review
- A Randomized, Double-Blind, Controlled Trial Protocol for Therapeutic Neuroscience Education in Chronic Migraine Patients: A Clinical-Neurophysiological Combined Study Design.Methods and protocols · 2025Article
- Instrumental assessment of pressure pain threshold over trigeminal and extra-trigeminal area in people with episodic and chronic migraine: a cross-sectional observational study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- The relationship between myofascial trigger points sensitivity, cervical postural abnormality, and clinical tension-type headache parameters.The Journal of manual & manipulative therapy · 2024Article
- Review
- Neuromodulation in Pediatric Migraine using Repetitive Neuromuscular Magnetic Stimulation: A Feasibility Study.Children (Basel, Switzerland) · 2023Article
- Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache - A retrospective exploratory study.Musculoskeletal science & practice · 2023Article
- Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients with Chronic Migraine: A Protocol for a Pilot Study Using a Single-Case Experimental Design.Medicina (Kaunas, Lithuania) · 2023Article
- Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine.iScience · 2023Article
- Pain sensitization and atrophy of deep cervical muscles in patients with chronic tension-type headache.Revista da Associacao Medica Brasileira (1992) · 2023Observational
- Inter-individual variability in mechanical pain sensation in patients with cervicogenic headache: an explorative study.Scientific reports · 2022Article
- Modulation of Central Nociceptive Transmission by Manual Pressure Techniques in Patients with Migraine: An Observational Study.Journal of clinical medicine · 2022Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSensitivity of tissues can be measured by algometry. Decreased pressure pain thresholds over the cranio-cervical area are supposed to reflect signs of sensitization of the trigemino-cervical nucleus caudalis. A systematic review was conducted to assess the current scientific literature describing pressure pain threshold (PPT) values over the cranio-cervical region in patients with migraine, tension-type headache (TTH), and cervicogenic headache (CeH). A literature search was executed in three databases. The search strategy included the following keywords: migraine, TTH, CeH, PPT and algometry. A total of 624 papers was identified of which relevant papers were subsequently assessed for methodological quality. Twenty-two selected papers were assessed by two independent reviewers and the majority of studies scored low risk of bias on the selected items. Mean PPT values of several sites measured in the cranio-cervical region in patients with migraine, chronic TTH and CeH scored lower values compared to controls. The trapezius muscle (midpoint between vertebrae C7 and acromion) was the most frequently targeted site and showed significantly lower PPT values in adults with migraine (pooled standardized mean difference kPa: 1.26 [95%CI -1.71, -0.81]) and chronic TTH (pooled standardized mean difference kPa: -2.00 [95%CI -2.93, -1.08]). Most studies found no association between PPT values and headache characteristics such as frequency, duration or intensity. Further standardization of PPT measurement in the cranio-cervical region is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.