ReviewPflugers Archiv : European journal of physiology2018
Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center.
Review in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Increasing Warmth in Oncological Patients: A Randomized Controlled Cross-Over Pilot Trial Examining the Efficacy of Mustard and Ginger Footbaths.Integrative cancer therapiesTrial
- Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention.Frontiers in pharmacology · 2026Review
- The neural thermostat malfunction: revisiting heatstroke through the lens of warm-sensitive neuron dysregulation.Frontiers in cellular neuroscience · 2026Review
- Article
- Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance.Nature neuroscience · 2025Article
- The short term impact of radiofrequency ablative techniques and peripheral nerve block on thermoregulation in mouse models.Scientific reports · 2024Article
- Chemogenetic Modulation of PreopticInternational journal of molecular sciences · 2024Article
- Endotherms trade body temperature regulation for the stress response.Proceedings. Biological sciences · 2023Article
- Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- How Temperature Influences Sleep.International journal of molecular sciences · 2022Review
- Human Stem Cell-Derived TRPV1-Positive Sensory Neurons: A New Tool to Study Mechanisms of Sensitization.Cells · 2022Article
- Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".International journal of molecular sciences · 2022Review
- Effect of Different Water Cooling Treatments on Changes in Rectal and Surface Body Temperature in Leisure Horses after Medium-Intensity Effort.Animals : an open access journal from MDPI · 2022Article
- Article
- A synaptic temperature sensor for body cooling.Neuron · 2021Article
- Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis.Science advances · 2021Article
- TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures.PLoS biology · 2021Article
- Impact of hypothermia on the biomechanical effect of epithelium-off corneal cross-linking.Eye and vision (London, England) · 2021Article
- Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice.Nature communications · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Temperature affects all aspects of life down to the diffusion rates of biologically active molecules and reaction rates of enzymes. The reciprocal argument holds true as well and every biological process down to enzymatic reactions influences temperature. In order to assure biological stability, mammalian organisms possess the remarkable ability to maintain internal body temperature within a narrow range, which in humans and mice is close to 37 °C, despite wide environmental temperature variations and different rates of internal heat production. Nevertheless, body temperature is not a static property but adaptively regulated upon physiological demands and in the context of pathological conditions. The brain region that has been primarily associated with internal temperature regulation is the preoptic area and the anterior portion of the hypothalamus. Similar to a thermostat, this brain area detects deep brain temperature, integrates temperature information from peripheral body sensors, and-based on these inputs--controls body temperature homeostasis. Discovered more than a century ago, we still know comparatively little about the molecular and cellular make-up of the hypothalamic thermoregulatory center. After a brief historic outline that led to the discovery of the thermoregulatory center, we here review recent studies that have considerably advanced our understanding of hypothalamic thermoregulation. We touch upon proposed mechanisms of intrinsic deep brain temperature detection and focus on newly identified hypothalamic cell populations that mediate thermoregulatory responses and that provide novel entry points not only to shed light on the mechanistic underpinnings of the thermoregulatory center but also to probe its therapeutic value.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.