ArticleScientific reports2018
Measurements of AMPs in stratum corneum of atopic dermatitis and healthy skin-tape stripping technique.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Cytokine concentration across the stratum corneum in atopic dermatitis and healthy controls.Scientific reports · 2020Trial
- Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.International journal of molecular sciences · 2026Article
- Optimization of protein extraction from skin tape strips for biomarker assessment.Scientific reports · 2026Article
- Human and Marine Host Defense Peptides for Healthy Skin.Marine drugs · 2026Review
- Advancing human skin models by integrating skin microbes for next-generation research.Scientific reports · 2026Article
- RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes.Scientific reports · 2025Article
- Use of D-SquameVeterinary sciences · 2024Article
- Article
- Solving the health disparity of eczema assessment: A role for skin tape soluble protein?The journal of allergy and clinical immunology. Global · 2024Article
- Article
- Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation.International journal of molecular sciences · 2023Article
- Antimicrobial Peptide Loss, Except for LL-37, is not Characteristic of Atopic Dermatitis.Acta dermato-venereologica · 2023Article
- Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC/Nga Mice.International journal of molecular sciences · 2023Article
- Interactions betweenInternational journal of molecular sciences · 2023Article
- Review
- The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.International journal of molecular sciences · 2021Review
- Dupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis.Allergy, asthma & immunology research · 2021Article
- Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry.International journal of molecular sciences · 2021Article
- Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council.The Journal of allergy and clinical immunology · 2021Review
- Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin.Allergy · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreased levels of antimicrobial peptides (AMPs) in atopic dermatitis (AD) have previously been reported and have been linked to the increased susceptibility to skin infections found in AD patients. This study intents to identify AMPs: hBD-2, hBD-3, RNase7, psoriasin and LL-37 in AD patients and healthy controls, and determine concentrations in consecutive depths of the outer most skin layers. Tape stripping was used on lesional and non-lesional skin. From each skin site, 35 consecutive tape strips were collected and pooled in groups of 5. Commercially available ELISA kits were used to determine AMP concentration in stratum corneum samples. hBD-2, hBD-3, RNase7 and psoriasin were identified in stratum corneum samples. hBD-3-level was markedly higher in AD non-lesional skin compared to healthy controls, and a similar trend was observed for RNase7. Most AMPs were distributed evenly through 35 tape strips, implying a homogeneous distribution of antimicrobial defense in the outer most skin layers. The findings indicate that AD patients may not suffer from a general baseline deficiency in AMPs, and that the innate immune defense is present throughout the stratum corneum, both insights of importance for understanding the role of AMPs in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.