Evidence map›Paper›PMID 29374221›Full record

ArticleScientific reports2018

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1

Qinming Zhou, Youjie Wang, Jingjing Zhang, Yaping Shao, Song Li, Yuan Wang, Huaibin Cai, Yi Feng, Weidong Le

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Herbal medicines for SOD1Frontiers in immunology · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Oxidative medicine and cellular longevity · 2020
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Qinming ZhouInstitute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, PR China.
Youjie WangEngineering Research Center of Modern Preparation Technology of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China.
Jingjing ZhangLiaoning Provincial Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, PR China.
Yaping ShaoLiaoning Provincial Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, PR China.
Song LiLiaoning Provincial Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, PR China.
Yuan WangEngineering Research Center of Modern Preparation Technology of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China.
Huaibin CaiLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20837, USA.ORCID http://orcid.org/0000-0002-8596-6108
Yi FengEngineering Research Center of Modern Preparation Technology of TCM, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China. fyi_shutcm@163.com.
Weidong LeInstitute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, PR China. wdle@sibs.ac.cn.
Dalian Medical University · CNShanghai University of Traditional Chinese Medicine · CNNational Institutes of Health · USShanghai Innovative Research Center of Traditional Chinese Medicine · CNShanghai Jiao Tong University · CN

Funding

The Pathogenic Mechanism of ALS-related VAPB MutationZIAAG000943 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2025
$6.8M
Striosomes Constrain Locomotor Vigor in Parkinson's disease and Other Movement DisordersZIAAG000959 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2024
$4.0M
The Function of dynactin p150glued in Axonal Transport and Motor Neuron DiseasesZIAAG000946 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2025
$3.0M
Intramural NIH HHS ZIA AG000959NIA NIH HHS ZIA AG000959
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive loss of motor neurons. There are no definitive pathogenic mechanisms and effective treatments for ALS now. Traditional Chinese medicine (TCM) plays an important role in Chinese health care system. Huolingshengji Formula (HLSJ) is a TCM formula which is applied for treating flaccid syndrome. Our previous clinical study has indicated that HLSJ may have therapeutic effects in ALS patients. In the present study, we analyzed the chemical profile of HLSJ by the high-performance liquid chromatographic (HPLC) fingerprint analysis. And we investigated the therapeutic effects and neuroprotective mechanisms of HLSJ against ALS in SOD1

Indexed as

Neuroprotective AgentsAmyotrophic Lateral SclerosisAnimalsChromatography, High Pressure LiquidDisease Models, AnimalDrugs, Chinese HerbalMiceMuscle, SkeletalMutation, MissenseSpinal CordSuperoxide Dismutase-1Treatment OutcomeDrugs, Chinese HerbalNeuroprotective AgentsSod1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID29374221
PMCPMC5786035
OpenAlexW2807002945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.