ArticleScientific reports2018
Different milk diets have substantial effects on the jejunal mucosal immune system of pre-weaning calves, as demonstrated by whole transcriptome sequencing.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Livestock immunomodulators as alternatives to antimicrobials - a roadmap for the fight against drug resistance.BMC veterinary research · 2026Review
- Interactions between rumen epithelium-associated microbiota and host immunological and metabolic adaptations in response to different milk replacer feeding intensities in dairy calves.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Using the conditioned place preference paradigm to assess hunger in dairy calves: Preliminary results and methodological issues.Animal welfare (South Mimms, England) · 2024Article
- Effect ofSaudi journal of biological sciences · 2023Article
- Effects of rumen cannulation combined with different pre-weaning feeding intensities on the intestinal, splenic and thymic immune system in heifer calves several month after surgery.Frontiers in immunology · 2023Article
- Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion.Scientific reports · 2022Article
- Analysis of Host Jejunum Transcriptome and Associated Microbial Community Structure Variation in Young Calves with Feed-Induced Acidosis.Metabolites · 2021Article
- Dynamic progression of the calf's microbiome and its influence on host health.Computational and structural biotechnology journal · 2021Review
- Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue.BMC genomics · 2019Article
- Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression.G3 (Bethesda, Md.) · 2019Article
- Molecular characterisation and risk factor analysis of Cryptosporidium spp. in calves from Italy.Parasitology research · 2018Article
- Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum mucosa of pre-weaning calves in response to different diets.Oncotarget · 2018Article
- Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that nutrition during early mammalian life has a strong influence on health and performance in later life. However, there are conflicting data concerning the appropriate milk diet. This discrepancy particularly applies to ruminants, a group of mammals that switch from monogastric status to rumination during weaning. Little is known regarding how the whole genome expression pattern in the juvenile ruminant gut is affected by alternative milk diets. Thus, we performed a next-generation-sequencing-based holistic whole transcriptome analysis of the jejunum in male pre-weaned German Holstein calves fed diets with restricted or unlimited access to milk during the first 8 weeks of life. Both groups were provided hay and concentrate ad libitum. The analysis of jejunal mucosa samples collected 80 days after birth and four weeks after the end of the feeding regimes revealed 275 differentially expressed loci. While the differentially expressed loci comprised 67 genes encoding proteins relevant to metabolism or metabolic adaptation, the most distinct difference between the two groups was the consistently lower activation of the immune system in calves that experienced restricted milk access compared to calves fed milk ad libitum. In conclusion, different early life milk diets had significant prolonged effects on the intestinal immune system.
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