ArticleNeurology2018
The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy.
Registry-linked trialAbstract read
In one paragraph
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01800214 (Prospective Neuroimaging, Cognition and Behavioural Study of Alzheimer's, Vascular, Parkinson's, Frontotemporal and Mixed Dementias), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Neuroimaging, Cognition and Behavioural Study of Alzheimer's, Vascular, Parkinson's, Frontotemporal and Mixed Dementias
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Gray matter asymmetry in asymptomatic carotid stenosis.Human brain mapping · 2021Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Neuropsychological criteria for Mild Cognitive Impairment (MCI) best identify neuroimaging-based risk profiles: A Department of Defense/Alzheimer's Disease Neuroimaging Initiative study.Journal of the International Neuropsychological Society : JINS · 2026Article
- Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes.Communications medicine · 2026Article
- Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase-derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive profile in burning mouth syndrome versus mild cognitive impairment: A comparative study.Oral diseases · 2025Article
- Association of vulnerable plaques with white matter hyperintensities on high-resolution magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition.Alzheimer's research & therapy · 2024Article
- Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI.Alzheimer's research & therapy · 2023Article
- Ten-Year Cardiovascular Disease Risk Score and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014.Journal of the American Heart Association · 2023Article
- Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke.Journal of the American Heart Association · 2023Article
- Combined Score of Perivascular Space Dilatation and White Matter Hyperintensities in Patients with Normal Cognition, Mild Cognitive Impairment, and Dementia.Medicina (Kaunas, Lithuania) · 2022Article
- Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults.JAMA network open · 2021Article
- Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.Neuroscience bulletin · 2021Article
- Observational
- Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities.Frontiers in neurology · 2021Review
- Automated White Matter Hyperintensity Segmentation Using Bayesian Model Selection: Assessment and Correlations with Cognitive Change.Neuroinformatics · 2020Article
- White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants.Human brain mapping · 2020Article
- Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures.Frontiers in neurology · 2020Article
- Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment.Translational stroke research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 4 institutions in 1 country.
Walter SwardfagerFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada. w.swardfager@utoronto.ca.
Hugo Cogo-MoreiraFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Mario MasellisFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Joel RamirezFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Nathan HerrmannFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Jodi D EdwardsFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Mahwesh SaleemFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Parco ChanFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Di YuFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Sean M NestorFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Christopher J M ScottFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Melissa F HolmesFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Demetrios J SahlasFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Alexander KissFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Paul I OhFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Stephen C StrotherFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Fuqiang GaoFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Bojana StefanovicFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Julia KeithFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Sean SymonsFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Richard H SwartzFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Krista L LanctôtFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Donald T StussFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
Sandra E BlackFrom Sunnybrook Research Institute (W.S., M.M., J.R., N.H., J.D.E., M.S., P.C., D.Y., S.M.N., C.J.M.S., M.F.H., A.K., P.I.O., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.), Toronto; University of Toronto (W.S., M.M., N.H., M.S., P.C., D.Y., S.M.N., A.K., P.I.O., S.C.S., F.G., B.S., J.K., S.S., R.H.S., K.L.L., D.T.S., S.E.B.); University Health Network Toronto Rehabilitation Institute (W.S., P.I.O., K.L.L.), Canada; Universidade Federal de São Paulo (H.C.-M.), Brazil; McMaster University (D.J.S., S.C.S.), Hamilton; and Rotman Research Institute (D.T.S.), Baycrest, Toronto, Canada.
University of Toronto · CAMcMaster University · CAToronto Rehabilitation Institute · CAUniversity Health Network · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the relationship between white matter hyperintensities (WMH) presumed to indicate disease of the cerebral small vessels, temporal lobe atrophy, and verbal memory deficits in Alzheimer disease (AD) and other dementias.
methodsWe recruited groups of participants with and without AD, including strata with extensive WMH and minimal WMH, into a cross-sectional proof-of-principle study (n = 118). A consecutive case series from a memory clinic was used as an independent validation sample (n = 702; Sunnybrook Dementia Study; NCT01800214). We assessed WMH volume and left temporal lobe atrophy (measured as the brain parenchymal fraction) using structural MRI and verbal memory using the California Verbal Learning Test. Using path modeling with an inferential bootstrapping procedure, we tested an indirect effect of WMH on verbal recall that depends sequentially on temporal lobe atrophy and verbal learning.
resultsIn both samples, WMH predicted poorer verbal recall, specifically due to temporal lobe atrophy and poorer verbal learning (proof-of-principle -1.53, 95% bootstrap confidence interval [CI] -2.45 to -0.88; and confirmation -0.66, 95% CI [-0.95 to -0.41] words). This pathway was significant in subgroups with (-0.20, 95% CI [-0.38 to -0.07] words, n = 363) and without (-0.71, 95% CI [-1.12 to -0.37] words, n = 339) AD. Via the identical pathway, WMH contributed to deficits in recognition memory (-1.82%, 95% CI [-2.64% to -1.11%]), a sensitive and specific sign of AD.
conclusionsAcross dementia syndromes, WMH contribute indirectly to verbal memory deficits considered pathognomonic of Alzheimer disease, specifically by contributing to temporal lobe atrophy.
Indexed as
MemorySpeech PerceptionAgedAged, 80 and overAlzheimer DiseaseAtrophyBrain IschemiaCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOrgan SizeProof of Concept Study
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NCT01800214ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.