Evidence map›Paper›PMID 29374075›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity.

Blake F Frey, Jiansheng Jiang, Yongjun Sui, Lisa F Boyd, Bin Yu, Gwen Tatsuno, Rolf Billeskov, Shahram Solaymani-Mohammadi, Phillip W Berman, David H Margulies and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  5. Structural and physical features that distinguish tumor-controlling from inactive cancer neoepitopes.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Blake F FreyVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Jiansheng JiangMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.ORCID 0000-0003-0964-5481
Yongjun SuiVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; suiy@mail.nih.gov.ORCID 0000-0002-1568-4607
Lisa F BoydMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.ORCID 0000-0002-5126-6250
Bin YuDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-3705-0453
Gwen TatsunoDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064.
Rolf BilleskovVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-4533-7304
Shahram Solaymani-MohammadiVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Phillip W BermanDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064.
David H MarguliesMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.ORCID 0000-0001-8530-7375
Jay A BerzofskyVaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
National Institutes of Health · USUniversity of California, Santa Cruz · US

Funding

Vaccine and immunotherapy strategies for cancer and viruses causing cancerZIASC004020 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 2009 to 2025
$51.8M
Molecular Interactions Of Lymphoid Cell ReceptorsZIAAI000622 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MARGULIES, DAVID · 2009 to 2025
$11.0M
Antigen-specific T-cell activation, vaccines for CancerZ01SC004020 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 1996 to 2008
$3.8M
Refocusing the Immune Response to the HIV Envelope GlycoproteinR01AI089378 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BERMAN, PHILLIP WAYNE · 2010 to 2013
$3.1M
Intramural NIH HHS Z01 SC004020NIAID NIH HHS R01 AI089378
6 · The paper itself

Abstract

Unlike cytosolic processing and presentation of viral Ags by virus-infected cells, Ags first expressed in infected nonprofessional APCs, such as CD4

Indexed as

AnimalsAntigen PresentationCathepsinsCD4-Positive T-LymphocytesCross-PrimingDendritic CellsEpitopes, T-LymphocyteHEK293 CellsHistocompatibility Antigens Class IHIVHIV Envelope Protein gp120HIV InfectionsHumansImmune EvasionImmunodominant EpitopesMicecathepsin SCathepsinsEpitopes, T-LymphocyteHistocompatibility Antigens Class IHIV Envelope Protein gp120Immunodominant EpitopesPeptides

Identifiers

PMID29374075
PMCPMC5890335
OpenAlexW2785241595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.