Evidence map›Paper›PMID 29374044›Full record

ArticleJournal of the American Heart Association2018

Inhibitory Effect of Vascular Endothelial Growth Factor on the Slowly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes.

Zhenhao Lin, Wenlu Xing, Chuanyu Gao, Xianpei Wang, Datun Qi, Guoyou Dai, Wen Zhao, Ganxin Yan

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zhenhao LinDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Wenlu XingDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Chuanyu GaoDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China gaocy6208@163.com.
Xianpei WangDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Datun QiDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Guoyou DaiDepartment of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Wen ZhaoSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Ganxin YanMain Line Health Heart Center, Lankenau Institute for Medical Research, Wynnewood, PA.
Zhengzhou University · CNMain Line Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular endothelial growth factor (VEGF) exerts a number of beneficial effects on ischemic myocardium via its angiogenic properties. However, little is known about whether VEGF has a direct effect on the electrical properties of cardiomyocytes. In the present study, we investigated the effects of different concentrations of VEGF on delayed rectifier potassium currents (I METHODS AND

resultsI

conclusionsVEGF inhibited I

Indexed as

Action PotentialsAnimalsAnti-Arrhythmia AgentsDose-Response Relationship, DrugFemaleGuinea PigsHeart VentriclesMyocytes, CardiacPhosphatidylinositol 3-KinasePotassium Channel BlockersPotassium Channels, Voltage-GatedRecombinant ProteinsSignal TransductionTime FactorsVascular Endothelial Growth Factor AAnti-Arrhythmia AgentsPhosphatidylinositol 3-KinasePotassium Channel Blockerspotassium channel protein I(sk)Potassium Channels, Voltage-GatedRecombinant ProteinsVascular Endothelial Growth Factor Aaction potentialarrhythmiaphosphatidylinositol 3‐kinasepotassium channelsvascular endothelial growth factor

Identifiers

PMID29374044
PMCPMC5850256
OpenAlexW2792103630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.