Evidence map›Paper›PMID 29374012›Full record

ArticleEMBO molecular medicine2018

miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders.

Michael E Widlansky, David M Jensen, Jingli Wang, Yong Liu, Aron M Geurts, Alison J Kriegel, Pengyuan Liu, Rong Ying, Guangyuan Zhang, Marc Casati and 7 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. microRNA and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
  8. Review
  9. Article
  10. Proteomic Profiles of Human Arterioles Isolated From Fresh Adipose Tissue or Following Overnight Storage.Laboratory investigation; a journal of technical methods and pathology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Broad-acting therapeutic effects of miR-29b-chitosan on hypertension and diabetic complications.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  18. Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Michael E WidlanskyDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA mwidlans@mcw.edu mliang@mcw.edu.ORCID 0000-0002-1461-9707
David M JensenDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Jingli WangDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Yong LiuDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Aron M GeurtsDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Alison J KriegelDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Pengyuan LiuDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Rong YingDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Guangyuan ZhangDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Marc CasatiDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Chen ChuDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Mobin MalikDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Amberly BranumDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael J TannerDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Sudhi TyagiDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Kristie UsaDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Mingyu LiangDepartment of Physiology, Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA mwidlans@mcw.edu mliang@mcw.edu.ORCID 0000-0002-6970-989X
Medical College of Wisconsin · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Research ServicesP01HL082798 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W · 2006 to 2015
$22.0M
Regulatory RNA in Hypertension and Renal InjuryR01HL121233 · NHLBI · UNIVERSITY OF ARIZONA · PI MINGYU LIANG · 2014 to 2026
$3.8M
J. NRSA Training CoreTL1TR001437 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI THOMAS, DANNY GEORGE · 2015 to 2024
$3.7M
Endothelial function in human diabetes: role of mitochondrial fission proteinsR01HL128240 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2016 to 2020
$2.9M
MicroRNA-29b and Endothelial FunctionR01HL125409 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI LIANG, MINGYU, WIDLANSKY, MICHAEL E · 2015 to 2018
$2.0M
Anesthesiology Research Training ProgramT32GM089586 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI EBERT, THOMAS JAY · 2010 to 2019
$1.5M
Importance of Mitochondria in the Endothelial Dysfunction of Type 2 DiabetesK23HL089326 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2009 to 2013
$680k
NCATS NIH HHS TL1 TR001437NCATS NIH HHS UL1 TR001436NHLBI NIH HHS K23 HL089326NHLBI NIH HHS P01 HL082798NHLBI NIH HHS R01 HL121233NHLBI NIH HHS R01 HL125409NHLBI NIH HHS R01 HL128240NIDDK NIH HHS U24 DK076169NIGMS NIH HHS T32 GM089586
6 · The paper itself

Abstract

We investigated the role of microRNAs (miRNA) in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR-29 was dysregulated in resistance arterioles obtained by biopsy in T2DM patients. Intraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human subjects or rats or targeted mutation of

Indexed as

AdultAgedAnimalsArteriolesCardiovascular DiseasesDiabetes Mellitus, Type 2Disease Models, AnimalEndothelium, VascularGene Expression RegulationHumansMicroRNAsMiddle AgedNitric OxideRatsVascular ResistanceVasodilationMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, ratNitric OxidediabetesendotheliumhypertensionmicroRNAnitric oxide

Identifiers

PMID29374012
PMCPMC5840545
OpenAlexW2784541502

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.