ArticleReproductive biology and endocrinology : RB&E2018
Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos.
Article in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Evidence-based clinical prioritization of embryos with mosaic results: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2021Pooled it
- Article
- Advanced strategies for single embryo selection in assisted human reproduction: A review of clinical practice and research methods.Clinical and experimental reproductive medicine · 2025Article
- Embryo Mosaicism Rate in National Referral Hospital of Indonesia Detected Using Next-Generation Sequencing: A Retrospective Study.International journal of fertility & sterility · 2025Article
- Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordance.Human reproduction open · 2024Article
- A review of the 2021/2022 PGDIS Position Statement on the transfer of mosaic embryos.Journal of assisted reproduction and genetics · 2023Review
- What proportion of embryos should be considered for transfer following a mosaic diagnosis? A study of 115 clinics from a central diagnostic laboratory.Journal of assisted reproduction and genetics · 2023Article
- Preimplantation genetic testing for aneuploidy: The management of mosaic embryos.Clinical and experimental reproductive medicine · 2022Article
- Factors affecting clinical manifestation of chromosomal imbalance in carriers of segmental autosomal mosaicism: differential impact of gender.Journal of applied genetics · 2022Review
- Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos.Journal of developmental biology · 2021Review
- Chromosomal mosaicism: Origins and clinical implications in preimplantation and prenatal diagnosis.Prenatal diagnosis · 2021Article
- Commentary on two recently published formal guidelines on management of "mosaic" embryos after preimplantation genetic testing for aneuploidy (PGT-A).Reproductive biology and endocrinology : RB&E · 2021Article
- Relationship between age and blastocyst chromosomal ploidy analyzed by noninvasive preimplantation genetic testing for aneuploidies (niPGT-A).JBRA assisted reproduction · 2020Article
- ROC and AUC with a Binary Predictor: a Potentially Misleading Metric.Journal of classification · 2020Article
- Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2020Article
- Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR.Genes · 2020Article
- Clinical Outcomes of Single Mosaic Embryo Transfer: High-Level or Low-Level Mosaic Embryo, Does it Matter?Journal of clinical medicine · 2020Article
- The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A.Reproductive biology and endocrinology : RB&E · 2020Article
- The mechanisms and clinical application of mosaicism in preimplantation embryos.Journal of assisted reproduction and genetics · 2020Review
- The PGS/PGT-A controversy in IVF addressed as a formal conflict resolution analysis.Journal of assisted reproduction and genetics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPreimplantation genetic screening (PGS) is increasingly utilized as an adjunct procedure to IVF. Recently healthy euploid live birth were reported following transfer of mosaic embryos. Several recent publications have surmised that the degree of trophectoderm (TE) mosaicism in transferred embryos is predictive of ongoing pregnancy and miscarriage rates.
methodsThis is a corrected analysis of previously published retrospective data on vitro fertilization (IVF) cycle outcomes involving replacement of 143 mosaic and 1045 euploid embryos tested by PGS, utilizing high-resolution next-generation sequencing (NGS) of TE and determination of percentages of mosaicism. Receiver operating curves (ROCs) and measurement of area under the curve (AUC) were used to evaluated the accuracy of the predictor variable, proportion of aneuploid cells in a TE biopsy specimen, with IVF outcomes, ongoing pregnancy and miscarriage rates.
resultsConfirming findings of the previously published report we also found higher ongoing pregnancy rates (63.3% vs. 39.2%) and lower miscarriage rates (10.2% vs. 24.3%) with euploid embryo transfers than with mosaic embryo transfer. There, however, were no significant differences in ongoing pregnancy or miscarriage rates among mosaic embryo transfers at any threshold of aneuploidy. Based on AUC, TE biopsies predicted ongoing pregnancy for euploid, as well as mosaic embryos, in a range of 0.50 to 0.59 and miscarriage in a range from 0.50 to 0.66
conclusionsDegree of TE mosaicism was a poor predictor of ongoing pregnancy and miscarriage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.