Evidence map›Paper›PMID 29373946›Full record

ArticleJournal of neurotrauma2018

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury.

Nandadevi Patil, Vincent Truong, Mackenzie H Holmberg, Nicolas S Lavoie, Mark R McCoy, James R Dutton, Eric G Holmberg, Ann M Parr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nandadevi Patil1 Department of Neurosurgery, Stem Cell Institute, University of Minnesota , Minneapolis, Minnesota.
Vincent Truong1 Department of Neurosurgery, Stem Cell Institute, University of Minnesota , Minneapolis, Minnesota.
Mackenzie H Holmberg2 Department of Chemistry, University of Alaska Anchorage , Anchorage, Alaska.
Nicolas S Lavoie1 Department of Neurosurgery, Stem Cell Institute, University of Minnesota , Minneapolis, Minnesota.
Mark R McCoy2 Department of Chemistry, University of Alaska Anchorage , Anchorage, Alaska.
James R Dutton4 Department of Genetics, Cell Biology and Development, Stem Cell Institute, University of Minnesota , Minneapolis, Minnesota.
Eric G Holmberg2 Department of Chemistry, University of Alaska Anchorage , Anchorage, Alaska.
Ann M Parr1 Department of Neurosurgery, Stem Cell Institute, University of Minnesota , Minneapolis, Minnesota.
University of Minnesota · USUniversity of Alaska Anchorage · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Institutional Career Development CoreKL2TR002492 · NCATS · UNIVERSITY OF MINNESOTA · PI INGBAR, DAVID H · 2018 to 2022
$6.3M
NCATS NIH HHS KL2 TR002492NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

There are no effective therapies available currently to ameliorate loss of function for patients with spinal cord injuries (SCIs). In addition, proposed treatments that demonstrated functional recovery in animal models of acute SCI have failed almost invariably when applied to chronic injury models. Glial scar formation in chronic injury is a likely contributor to limitation on regeneration. We have removed existing scar tissue in chronically contused rat spinal cord using a rose Bengal-based photo ablation approach. In this study, we compared two chemically modified rose bengal derivatives to unmodified rose bengal, both confirming and expanding on our previously published report. Rats were treated with unmodified rose bengal (RB1) or rose bengal modified with hydrocarbon (RB2) or polyethylene glycol (RB3), to determine the effects on scar components and spared tissue post-treatment. Our results showed that RB1 was more efficacious than RB2, while still maintaining minimal collateral effects on spared tissue. RB3 was not taken up by the cells, likely because of its size, and therefore had no effect. Treatment with RB1 also resulted in an increase in serotonin eight days post-treatment in chronically injured spinal cords. Thus, we suggest that unmodified rose Bengal is a potent candidate agent for the development of a therapeutic strategy for scar ablation in chronic SCI.

Indexed as

AnimalsChronic DiseaseCicatrixFluorescent DyesNerve RegenerationNeurogliaPhototherapyRatsRats, Long-EvansRecovery of FunctionRose BengalSpinal Cord InjuriesFluorescent DyesRose Bengalchronic spinal cord injuryphotochemical scar ablationrose Bengal

Identifiers

PMID29373946
PMCPMC6033306
OpenAlexW2786929870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.