Evidence map›Paper›PMID 29373859›Full record

ArticleEnvironmental health perspectives2017

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study.

Shohreh F Farzan, Caitlin G Howe, Michael S Zens, Thomas Palys, Jacqueline Y Channon, Zhigang Li, Yu Chen, Margaret R Karagas

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  14. Anti-oxidant Effect of High Dilutions ofDose-response : a publication of International Hormesis Society
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shohreh F FarzanDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA
Caitlin G HoweDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA
Michael S ZensDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
Thomas PalysCenter for Molecular Epidemiology at Dartmouth, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
Jacqueline Y ChannonDepartment of Microbiology and Immunology and Norris Cotton Cancer Center, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
Zhigang LiDepartment of Biomedical Data Science, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
Yu ChenDepartment of Population Health, New York University School of Medicine, New York, New York, USA
Margaret R KaragasDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
Dartmouth College · USUniversity of Southern California · USNew York University · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
NONMELANOMA SKIN CANCER IN NEW HAMPSHIRER01CA057494 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1993 to 2015
$10.9M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
Center for Molecular, Cellular, and Translational ImmunologyP30GM103415 · NIGMS · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2012 to 2015
$4.7M
Training Program for Quantitative Population Sciences in CancerR25CA134286 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, TOSTESON, TOR D · 2009 to 2018
$3.0M
Mediation Analysis Methods to Model Human Microbiome Mediating Disease-Leading Causal Pathways in ChildrenR01GM123014 · NIGMS · UNIVERSITY OF FLORIDA · PI LI, ZHIGANG · 2017 to 2021
$2.1M
Preclinical Indicators & Biomarkers of Cardiovascular Effects of Arsenic ExposureR00ES024144 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2016 to 2018
$746k
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA057494NCI NIH HHS R25 CA134286NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES024144NIEHS NIH HHS T32 ES013678NIGMS NIH HHS P20 GM104416NIGMS NIH HHS P30 GM103415NIGMS NIH HHS R01 GM123014
6 · The paper itself

Abstract

backgroundArsenic (As) exposure has been associated with increased risk for cardiovascular disease (CVD) and with biomarkers of potential CVD risk and inflammatory processes. However, few studies have evaluated the effects of As on such biomarkers in U.S. populations, which are typically exposed to low to moderate As concentrations.

objectivesWe investigated associations between As exposures and biomarkers relevant to inflammation, oxidative stress, and CVD risk in a subset of participants from the New Hampshire Health Study, a population with low to moderate As exposure (

methodsAssociations between toenail As, total urine As (uAs), and %uAs metabolites [monomethyl (%uMMA

resultsCovariate-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 15-F

conclusionIn a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062.

Indexed as

Oxidative StressAgedArsenicBiomarkersCross-Sectional StudiesEnvironmental ExposureFemaleHumansInflammationMaleMiddle AgedNew HampshireVascular DiseasesArsenicBiomarkers

Identifiers

PMID29373859
PMCPMC5963594
OpenAlexW2794399865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.