Evidence map›Paper›PMID 29373802›Full record

ArticleAmerican journal of respiratory and critical care medicine2018

Positive End-Expiratory Pressure Lower Than the ARDS Network Protocol Is Associated with Higher Pediatric Acute Respiratory Distress Syndrome Mortality.

Robinder G Khemani, Kaushik Parvathaneni, Nadir Yehya, Anoopindar K Bhalla, Neal J Thomas, Christopher J L Newth

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06020404 (Physiological Effects of Prone vs. sUpine Position on Lung Recruitability in infantS/Children With Acute Respiratory Distress Syndrome), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06020404 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Physiological Effects of Prone vs. sUpine Position on Lung Recruitability in infantS/Children With Acute Respiratory Distress Syndrome

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2023 to 2025Enrolled15ConditionsProne Position, Acute Respiratory Distress SyndromeArmssupine position, prone position
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Guideline
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  3. Review
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  5. Article
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  7. Review
  8. Article
  9. Esophageal Manometry in Pediatric Acute Respiratory Distress Syndrome: Necessity or Simply a Neighbor of the Pulmonary Artery Catheter?Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Critical Care of the Pediatric Burn Patient.Seminars in plastic surgery · 2024
    Review
  14. Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2024
    Article
  15. Article
  16. Article
  17. Extracorporeal Membrane Oxygenation.Respiratory care · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Robinder G Khemani1 Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0002-5815-0314
Kaushik Parvathaneni1 Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Nadir Yehya4 Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania; and.
Anoopindar K Bhalla1 Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Neal J Thomas5 Division of Pediatric Critical Care Medicine, Department of Pediatrics and Public Health Science, Penn State Hershey Children's Hospital, Hershey, Pennsylvania.
Christopher J L Newth1 Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Children's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USPenn State Milton S. Hershey Medical Center · USUniversity of Southern California · US

Funding

Clinical and Proteomic Characterization of Nucleosomes in Pediatric Acute Respiratory Distress SyndromeK23HL136688 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI YEHYA, NADIR · 2017 to 2020
$694k
Translating an Adult Ventilator Computer Protocol to Pediatric Critical CareR21HD061870 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEWTH, CHRISTOPHER JOHN, SWARD, KATHERINE ANN · 2011 to 2012
$450k
NHLBI NIH HHS K23 HL136688NHLBI NIH HHS L40 HL134039NICHD NIH HHS R21 HD061870
6 · The paper itself

Abstract

rationaleThe ARDS Network (ARDSNet) used a positive end-expiratory pressure (PEEP)/Fi

objectivesTo evaluate whether children managed with PEEP lower than recommended by the ARDSNet PEEP/Fi

methodsThis was a multicenter, retrospective analysis of patients with pediatric acute respiratory distress syndrome (PARDS) managed without a formal PEEP/Fi MEASUREMENTS AND MAIN

resultsOf the 1,134 patients with PARDS, 26.6% were managed with lower PEEP relative to the amount of Fi

conclusionsPatients with PARDS managed with lower PEEP relative to Fi

Indexed as

Practice Guidelines as TopicChildChild, PreschoolFemaleHumansInfantMalePediatricsPositive-Pressure RespirationRetrospective StudiesSevere Acute Respiratory Syndromeacute lung injuryacute respiratory distress syndromeARDS Networkpediatricspositive end expiratory pressure

Identifiers

PMID29373802
PMCPMC6034123
OpenAlexW2786127686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.