ArticleAmerican journal of respiratory and critical care medicine2018
Does Extracorporeal Membrane Oxygenation Improve Survival in Pediatric Acute Respiratory Failure?
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sedation Management in Pediatric Patients With Acute Respiratory Failure
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Consensus statement of the Paediatric Anaesthesiology and Intensive Therapy Section of the Polish Society of Anaesthesiology and Intensive Therapy on the use of VV ECMO in paediatric patients for the treatment of acute respiratory failure.Anaesthesiology intensive therapy · 2026Article
- Evaluation of extracorporeal membrane oxygenation in children with acute hypoxemic respiratory failure and hemodynamic instability in China: a 7-year single-center retrospective study.Frontiers in medicine · 2026Article
- Cost-effectiveness of the timing of respiratory extracorporeal membrane oxygenation initiation in pediatric patients.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Article
- Outcomes of Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome in Pediatric Trauma Patients.Critical care explorations · 2024Observational
- Association between mechanical ventilation parameters and mortality in children with respiratory failure on ECMO: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Review
- Necrotizing pneumonia requiring prolonged extracorporeal membrane oxygenation: Pushing the boundaries in pediatric ECMO.Clinical case reports · 2022Article
- Bridging Children to Lung Transplantation Using Extracorporeal Membrane Oxygenation.Annals of the American Thoracic Society · 2022Article
- Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome in children with leukemia/lymphoma: A retrospective case series.Frontiers in pediatrics · 2022Article
- Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin.Bioengineered · 2021Article
- Bridging the Gap Between Intensivists and Primary Care Clinicians in Extracorporeal Membrane Oxygenation for Respiratory Failure in Children: A Review.JAMA pediatrics · 2021Review
- Paediatrics: how to manage acute respiratory distress syndrome.Drugs in context · 2021Review
- Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research.American journal of respiratory and critical care medicine · 2020Article
- Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children-a population-based cohort study.Critical care (London, England) · 2020Article
- What's new in paediatric extracorporeal life support?Intensive care medicine · 2020Article
- Neurologic Outcomes in a Two-Center Cohort of Neonatal and Pediatric Patients Supported on Extracorporeal Membrane Oxygenation.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Observational
- Venoarterial Extracorporeal Membrane Oxygenation for Severe Neonatal Acute Respiratory Distress Syndrome in a Developing Country.Frontiers in pediatrics · 2020Article
- Paediatric respiratory distress.BJA education · 2019Review
- Extra-corporeal membrane oxygenation in paediatric acute respiratory distress syndrome: overrated or underutilized?Annals of translational medicine · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
rationaleExtracorporeal membrane oxygenation (ECMO) has supported gas exchange in children with severe respiratory failure for more than 40 years, without ECMO efficacy studies.
objectivesTo compare the mortality and functional status of children with severe acute respiratory failure supported with and without ECMO.
methodsThis cohort study compared ECMO-supported children to pair-matched non-ECMO-supported control subjects with severe acute respiratory distress syndrome (ARDS). Both individual case matching and propensity score matching were used. The study sample was selected from children enrolled in the cluster-randomized RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) clinical trial. Detailed demographic and daily physiologic data were used to match patients. The primary endpoint was in-hospital mortality. Secondary outcomes included hospital-free days, ventilator-free days, and change in functional status at hospital discharge. MEASUREMENTS AND MAIN
resultsOf 2,449 children in the RESTORE trial, 879 (35.9%) non-ECMO-supported patients with severe ARDS were eligible to match to 61 (2.5%) ECMO-supported children. When individual case matching was used (60 matched pairs), the in-hospital mortality rate at 90 days was 25% (15 of 60) for both the ECMO-supported and non-ECMO-supported children (P > 0.99). With propensity score matching (61 matched pairs), the ECMO-supported in-hospital mortality rate was 15 of 61 (25%), and the non-ECMO-supported hospital mortality rate was 18 of 61 (30%) (P = 0.70). There was no difference between ECMO-supported and non-ECMO-supported patients in any secondary outcomes.
conclusionsIn children with severe ARDS, our results do not demonstrate that ECMO-supported children have superior outcomes compared with non-ECMO-supported children. Definitive answers will require a rigorous multisite randomized controlled trial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.