ArticleMolecular biology and evolution2018
Whole-Body Single-Cell Sequencing Reveals Transcriptional Domains in the Annelid Larval Body.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Cell fate specification modes shape transcriptome evolution in the highly conserved spiral cleavage.EMBO reports · 2025Article
- Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology.Aging and disease · 2025Review
- Microalgal biofilm induces larval settlement in the model marine wormRoyal Society open science · 2024Article
- Review
- Annelid adult cell type diversity and their pluripotent cellular origins.Nature communications · 2024Article
- Marine Invertebrates One Cell at A Time: Insights from Single-Cell Analysis.Integrative and comparative biology · 2023Review
- Single-cell transcriptomics refuels the exploration of spiralian biology.Briefings in functional genomics · 2023Review
- Functional genomics in Spiralia.Briefings in functional genomics · 2023Article
- Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii.BMC genomics · 2023Article
- Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories.Science advances · 2023Article
- Article
- Cell types as species: Exploring a metaphor.Frontiers in plant science · 2022Review
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Article
- Acoel Single-Cell Transcriptomics: Cell Type Analysis of a Deep Branching Bilaterian.Molecular biology and evolution · 2021Article
- Elementary nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Open Frontiers in Neural Cell Type Investigations; Lessons FromFrontiers in neuroscience · 2021Review
- Lineage tracing meets single-cell omics: opportunities and challenges.Nature reviews. Genetics · 2020Review
- From spiral cleavage to bilateral symmetry: the developmental cell lineage of the annelid brain.BMC biology · 2019Article
- Review
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11 authors.
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Abstract
Animal bodies comprise diverse arrays of cells. To characterize cellular identities across an entire body, we have compared the transcriptomes of single cells randomly picked from dissociated whole larvae of the marine annelid Platynereis dumerilii. We identify five transcriptionally distinct groups of differentiated cells, each expressing a unique set of transcription factors and effector genes that implement cellular phenotypes. Spatial mapping of cells into a cellular expression atlas, and wholemount in situ hybridization of group-specific genes reveals spatially coherent transcriptional domains in the larval body, comprising, for example, apical sensory-neurosecretory cells versus neural/epidermal surface cells. These domains represent new, basic subdivisions of the annelid body based entirely on differential gene expression, and are composed of multiple, transcriptionally similar cell types. They do not represent clonal domains, as revealed by developmental lineage analysis. We propose that the transcriptional domains that subdivide the annelid larval body represent families of related cell types that have arisen by evolutionary diversification. Their possible evolutionary conservation makes them a promising tool for evo-devo research.
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