ArticleChemical senses2018
Identification of Odor Blend Used by Caenorhabditis elegans for Pathogen Recognition.
Article in Chemical senses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.Current biology : CB · 2026Article
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- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior inbioRxiv : the preprint server for biology · 2025Article
- The AWCmicroPublication biology · 2025Article
- β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.iScience · 2024Article
- A non-invasive screening method usingBiochemistry and biophysics reports · 2024Article
- Chemosensory detection of polyamine metabolites guidesScience advances · 2024Article
- Chemical basis of microbiome preference in the nematode C. elegans.Scientific reports · 2024Article
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- The nematode wormeLife · 2023Article
- Recent Advances in Life History Transition with Nematode-Trapping FungusPathogens (Basel, Switzerland) · 2023Review
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- 1-Undecene from Pseudomonas aeruginosa is an olfactory signal for flight-or-fight response in Caenorhabditis elegans.The EMBO journal · 2021Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- The Scent of Life: Phoretic Nematodes Use Wasp Volatiles and Carbon Dioxide to Choose Functional Vehicles for Dispersal.Journal of chemical ecology · 2021Article
- G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans.PLoS pathogens · 2021Review
- Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways.Nature communications · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Animals have evolved specialized pathways to detect appropriate food sources and avoid harmful ones. Caenorhabditis elegans can distinguish among the odors of various species of bacteria, its major food source, but little is known about what specific chemical cue or combination of chemical cues C. elegans uses to detect and recognize different microbes. Here, we examine the strong innate attraction of C. elegans for the odor of the pathogenic bacterium, Serratia marcescens. This initial attraction likely facilitates ingestion and infection of the C. elegans host. Using solid-phase microextraction and gas chromatography coupled with mass spectrometry, we identify 5 volatile odors released by S. marcescens and identify those that are attractive to C. elegans. We use genetic methods to show that the amphid chemosensory neuron, AWCON, senses both S. marcescens-released 2-butanone and acetone and drives attraction to S. marcescens. In C. elegans, pairing a single odorant with food deprivation results in a reduced attractive response for that specific odor. We find that pairing the natural odor of S. marcescens with food deprivation results in a reduced attraction for the natural odor of S. marcescens and a similar reduced attraction for the synthetic blend of acetone and 2-butanone. This result indicates that only 2 odorants represent the more complex odor bouquet of S. marcescens. Although bacterial-released volatiles have long been known to be attractive to C. elegans, this study defines for the first time specific volatile cues that represent a particular bacterium to C. elegans.
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