ArticleCerebral cortex (New York, N.Y. : 1991)2019
Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- Distinct Visual Pathways of Threat Retrieval in Fear-Conditioned Faces.Psychophysiology · 2026Article
- Imagery-based fear conditioning enhances the late positive potential.Cognitive, affective & behavioral neuroscience · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- A systematic review of spontaneous recovery in human fear conditioning.Frontiers in behavioral neuroscience · 2026Review
- Contingency awareness shapes neural responses in fear conditioning.Neuroscience of consciousness · 2026Article
- Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition.Journal of magnetic resonance imaging : JMRI · 2025Article
- Developmental differences in threat learning are associated with changes in frontal-central theta activity.European child & adolescent psychiatry · 2025Article
- Applying Bayesian Multilevel Modeling to Single Trial Dynamics: A Demonstration in Aversive Conditioning.Human brain mapping · 2025Article
- Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors.Biological psychiatry global open science · 2025Article
- Emotional recognition technologies applied to health: review and challenges.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Review
- Evaluating multimodal physiological signals for fear detection: relative utility of pupillometry, heart rate, and EEG.Frontiers in human neuroscience · 2025Article
- PTSD-related differences in resting-state functional connectivity and associations with sex hormones.medRxiv : the preprint server for health sciences · 2024Article
- Conflict Dynamics of Post-Retrieval Extinction: A Comparative Analysis of Unconditional and Conditional Reminders Using Skin Conductance Responses and EEG.Brain topography · 2024Article
- Acquisition and generalization of emotional and neural responses to faces associated with negative and positive feedback behaviours.Frontiers in neuroscience · 2024Article
- Biobehavioral mechanisms underlying testosterone and mood relationships in peripubertal female adolescents.Development and psychopathology · 2023Article
- Changes in brain rhythms and connectivity tracking fear acquisition and reversal.Brain structure & function · 2023Article
- Behavioral pattern separation is associated with neural and electrodermal correlates of context-dependent fear conditioning.Scientific reports · 2023Article
- Rapid Unconscious Acquisition of Conditioned Fear with Low-Spatial-Frequency but Emotionally Neutral Stimuli.Research (Washington, D.C.) · 2023Article
- Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning.Science advances · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Human functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) studies, as well as animal studies, indicate that the amygdala and frontomedial brain regions are critically involved in conditioned fear and that frontomedial oscillations in the theta range (4-8 Hz) may support communication between these brain regions. However, few studies have used a multimodal approach to probe interactions among these key regions in humans. Here, our goal was to bridge the gap between prior human fMRI, EEG, and animal findings. Using simultaneous EEG-fMRI recordings 24 h after fear conditioning and extinction, conditioned stimuli presented (CS+E, CS-E) and not presented during extinction (CS+N, CS-N) were compared to identify effects specific to extinction versus fear recall. Differential (CS+ vs. CS-) electrodermal, frontomedial theta (EEG) and amygdala responses (fMRI) were reduced for extinguished versus nonextinguished stimuli. Importantly, effects on theta power covaried with effects on amygdala activation. Fear and extinction recall as indicated by theta explained 60% of the variance for the analogous effect in the right amygdala. Our findings show for the first time the interplay of amygdala and frontomedial theta activity during fear and extinction recall in humans and provide insight into neural circuits consistently linked with top-down amygdala modulation in rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.