ArticlePloS one2018
High dietary zinc feeding promotes persistence of multi-resistant E. coli in the swine gut.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 94 citations in OpenAlex.
- Robust detection in faeces andVeterinary and animal science · 2026Article
- The Effect of Zinc Gluconate Supplementation on the Intestinal Microbiota and Growth Performance of Yorkshire Pigs.Animals : an open access journal from MDPI · 2026Article
- Dietary iron and metal-based growth promoters differentially modulate the gut resistome and Escherichia coli virulome in weaned pigs.Journal of animal science and biotechnology · 2026Article
- Dietary iron and metal-based growth differentially modulate growth and gut microbiome of weaned piglets.Animal microbiome · 2026Article
- Producer perceptions on the impacts of the withdrawal of zinc oxide on the health and welfare of weaned pigs.Frontiers in veterinary science · 2026Article
- Zinc and animal health: an in-depth exploration of its role in physiological functions and regulatory molecular mechanisms.Journal of animal science and biotechnology · 2025Review
- Sodium Butyrate Supplementation in Whole Milk Modulates the Gastrointestinal Microbiota Without Altering the Resistome and Virulome in Preweaned Calves.Microorganisms · 2025Article
- A Low Dose of Berberine Is Metabolized in Weaned Piglets Without Major Changes to Gut Morphology or Gut Microbiota.Animals : an open access journal from MDPI · 2025Article
- In-feed provision of binding proteins sustains piglet gut health and mitigates ETEC-induced post-weaning diarrhea.Journal of animal science and biotechnology · 2025Article
- Effects of zinc oxide and monoglyceride blend on intestinal immune, health and microbiota responses of weanling pigs.Veterinary research communications · 2025Article
- Antimicrobial resistance in Escherichia coli from Swedish piglets with diarrhoea and associations with potential risk factors.Acta veterinaria Scandinavica · 2025Article
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Evaluation of dietary acid-binding capacity level on nursery pig growth performance and fecal dry matter.Journal of animal science · 2025Article
- Lactobacillus and Saccharomyces fermentation products impact performance and the fecal microbiome in weanling pigs inoculated with enterotoxigenic Escherichia coli.Journal of animal science · 2025Article
- Effects of low acid-binding capacity specialty soy protein sources on nursery pig performance in a commercial environment.Translational animal science · 2025Article
- Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action.Frontiers in veterinary science · 2025Article
- Effects of different doses and preparations of zinc oxide in weanling piglets on performance, intestinal microbiota and microbial metabolites.Translational animal science · 2025Article
- Feed supplementation with potentiated zinc and/or tannin-rich extracts reduces ETEC infection severity and antimicrobial resistance genes in pig.Frontiers in veterinary science · 2025Article
- The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function.International journal of molecular sciences · 2024Review
- Diversity and phage sensitivity to phages of porcine enterotoxigenicApplied and environmental microbiology · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High levels of zinc oxide are used frequently as feed additive in pigs to improve gut health and growth performance and are still suggested as an alternative to antimicrobial growth promoters. However, we have recently described an increase of multi-resistant E. coli in association to zinc feeding in piglets. This previous study focused on clonal diversity of E. coli, observing the effect on multi-resistant strains by chance. To shed further light into this highly important topic and falsify our previous findings, we performed a zinc pig feeding trial where we specifically focused on in-depth analysis of antimicrobial resistant E. coli. Under controlled experimental conditions, piglets were randomly allocated to a high dietary zinc (zinc group) and a background zinc feeding group (control group). At different ages samples were taken from feces, digesta, and mucosa and absolute E. coli numbers were determined. A total of 2665 E. coli isolates were than phenotypically tested for antimicrobial resistance and results were confirmed by minimum inhibitory concentration testing for random samples. In piglets fed with high dietary zinc, we detected a substantial increase of multi-resistant E. coli in all gut habitats tested, ranging from 28.9-30.2% multi-resistant E. coli compared to 5.8-14.0% in the control group. This increase was independent of the total number of E. coli. Interestingly, the total amount of the E. coli population decreased over time. Thus, the increase of the multi-resistant E. coli populations seems to be linked with persistence of the resistant population, caused by the influence of high dietary zinc feeding. In conclusion, these findings corroborate our previous report linking high dietary zinc feeding of piglets with the occurrence of antimicrobial resistant E. coli and therefore question the feeding of high dietary zinc oxide as alternative to antimicrobial growth promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.