ArticleLife (Basel, Switzerland)2018
Sustainability of a Compartmentalized Host-Parasite Replicator System under Periodic Washout-Mixing Cycles.
Article in Life (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Repetitive temperature cycles with DMSO sustain RNA replicating liposome compartments via fusion mediated content exchange.Communications biology · 2026Article
- Experimental evolution toward extinction in a molecular host-parasite system.Molecular biology and evolution · 2026Article
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Design of Novel Synthetic RNA Replicons Based onACS synthetic biology · 2024Article
- Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution.PLoS computational biology · 2022Article
- How evolution builds up complexity?: In vitro evolution approaches to witness complexification in artificial molecular replication systems.Biophysics and physicobiology · 2022Article
- Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.Life (Basel, Switzerland) · 2021Review
- Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution.eLife · 2020Article
- Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection.Life (Basel, Switzerland) · 2019Article
- Automated in vitro evolution of a translation-coupled RNA replication system in a droplet flow reactor.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The emergence and dominance of parasitic replicators are among the major hurdles for the proliferation of primitive replicators. Compartmentalization of replicators is proposed to relieve the parasite dominance; however, it remains unclear under what conditions simple compartmentalization uncoupled with internal reaction secures the long-term survival of a population of primitive replicators against incessant parasite emergence. Here, we investigate the sustainability of a compartmentalized host-parasite replicator (CHPR) system undergoing periodic washout-mixing cycles, by constructing a mathematical model and performing extensive simulations. We describe sustainable landscapes of the CHPR system in the parameter space and elucidate the mechanism of phase transitions between sustainable and extinct regions. Our findings revealed that a large population size of compartments, a high mixing intensity, and a modest amount of nutrients are important factors for the robust survival of replicators. We also found two distinctive sustainable phases with different mixing intensities. These results suggest that a population of simple host-parasite replicators assumed before the origin of life can be sustained by a simple compartmentalization with periodic washout-mixing processes.
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