ArticleSensors (Basel, Switzerland)2018
The Response of HeLa Cells to Fluorescent NanoDiamond Uptake.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Quantum Sensing of Free Radical Generation in Mitochondria of Human Keratinocytes during UVB Exposure.ACS sensors · 2024Article
- Quantum Sensing of Free Radical Generation in Mitochondria of Single Heart Muscle Cells during Hypoxia and Reoxygenation.ACS nano · 2024Article
- Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues.Analytical chemistry · 2023Article
- Diamond Quantum Sensing Revealing the Relation between Free Radicals and Huntington's Disease.ACS central science · 2023Article
- Fluorescent nanodiamond labels: Size and concentration matters for sperm cell viability.Materials today. Bio · 2023Article
- Intracellular Relaxometry, Challenges, and Future Directions.ACS central science · 2022Review
- Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells.ACS applied materials & interfaces · 2022Article
- Article
- General Method to Increase Carboxylic Acid Content on Nanodiamonds.Molecules (Basel, Switzerland) · 2022Article
- pH Sensitive Dextran Coated Fluorescent Nanodiamonds as a Biomarker for HeLa Cells Endocytic Pathway and Increased Cellular Uptake.Nanomaterials (Basel, Switzerland) · 2021Article
- Quantum monitoring of cellular metabolic activities in single mitochondria.Science advances · 2021Article
- Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation.ACS applied nano materials · 2021Article
- Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.Nanomaterials (Basel, Switzerland) · 2020Article
- Targeting Nanodiamonds to the Nucleus in Yeast Cells.Nanomaterials (Basel, Switzerland) · 2020Article
- The Fate of Lipid-Coated and Uncoated Fluorescent Nanodiamonds during Cell Division in Yeast.Nanomaterials (Basel, Switzerland) · 2020Article
- Evaluation of the Oxidative Stress Response of Aging Yeast Cells in Response to Internalization of Fluorescent Nanodiamond Biosensors.Nanomaterials (Basel, Switzerland) · 2020Article
- A Perspective on Fluorescent Nanodiamond Bioimaging.Small (Weinheim an der Bergstrasse, Germany) · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent nanodiamonds are promising probes for nanoscale magnetic resonance measurements. Their physical properties predict them to have particularly useful applications in intracellular analysis. Before using them in intracellular experiments however, it should be clear whether diamond particles influence cell biology. While cytotoxicity has already been ruled out in previous studies, we consider the non-fatal influence of fluorescent nanodiamonds on the formation of reactive oxygen species (an important stress indicator and potential target for intracellular sensing) for the first time. We investigated the influence of different sizes, shapes and concentrations of nanodiamonds on the genetic and protein level involved in oxidative stress-related pathways of the HeLa cell, an important model cell line in research. The changes in viability of the cells and the difference in intracellular levels of free radicals, after diamond uptake, are surprisingly small. At lower diamond concentrations, the cellular metabolism cannot be distinguished from that of untreated cells. This research supports the claims of non-toxicity and includes less obvious non-fatal responses. Finally, we give a handhold concerning the diamond concentration and size to use for non-toxic, intracellular measurements in favour of (cancer) research in HeLa cells.
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