Evidence map›Paper›PMID 29373456›Full record

SynthesisThe Journal of nervous and mental disease2018

Natural Medicines for Psychotic Disorders: A Systematic Review.

H J Rogier Hoenders, Agna A Bartels-Velthuis, Nina K Vollbehr, Richard Bruggeman, Henderikus Knegtering, Joop T V M de Jong

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in The Journal of nervous and mental disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Opportunities in Novel Psychotropic Drug Design from Natural Compounds.The international journal of neuropsychopharmacology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

H J Rogier Hoenders
Agna A Bartels-Velthuis
Nina K Vollbehr
Richard Bruggeman
Henderikus Knegtering
Joop T V M de Jong
Integra (United States) · USUniversity of Amsterdam · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive dyskinesia and akathisia. Results on other compounds were negative or inconclusive. All natural agents, except reserpine, were well tolerated. Most study samples were small, study periods were generally short, and most results need replication. However, there is some evidence for beneficial effects of certain natural medicines.

Indexed as

Antipsychotic AgentsComplementary TherapiesGinkgo bilobaGinkgo ExtractHumansMedicine, AyurvedicMedicine, Chinese TraditionalPhytotherapyPlant ExtractsPsychotic DisordersTreatment OutcomeAntipsychotic AgentsGinkgo biloba extractGinkgo ExtractPlant Extracts

Identifiers

PMID29373456
PMCPMC5794244
OpenAlexW2784568067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.