Evidence map›Paper›PMID 29373286›Full record

ArticleMolecular metabolism2018

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.

Robin Sachdeva, Andrea Schlotterer, Dagmar Schumacher, Christin Matka, Ilka Mathar, Nadine Dietrich, Rebekka Medert, Ulrich Kriebs, Jihong Lin, Peter Nawroth and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  6. The Variety of Mechanosensitive Ion Channels in Retinal Neurons.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review
  10. Article
  11. Review
  12. Article
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  17. Article
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  19. Review
  20. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Robin SachdevaInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Andrea SchlottererVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dagmar SchumacherInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Christin MatkaInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Ilka MatharInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Nadine DietrichVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Rebekka MedertInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Ulrich KriebsInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Jihong LinVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Peter NawrothDepartment of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Germany; German Center for Diabetes Research (DZD), Germany; Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Dept. of Medicine I, Heidelberg University Hospital, Heidelberg, Germany.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, North Carolina, USA; Institute for Biomedical Research (BIOMED), School of Medical sciences, Catholic University of Argentina, Buenos Aires, Argentina.
Thomas FlemingDepartment of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Germany; German Center for Diabetes Research (DZD), Germany.
Hans-Peter HammesVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marc FreichelInstitute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address: marc.freichel@pharma.uni-heidelberg.de.
Heidelberg University · DEPontificia Universidad Católica Argentina · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDiabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6

methodsWe used Nanostring- and qPCR-based analysis to determine mRNA levels of TRPC channels in control and diabetic retinae and retinal cell types. Chronic hyperglycemia was induced by Streptozotocin (STZ) treatment. To assess the development of diabetic retinopathy, vasoregression, pericyte loss, and thickness of individual retinal layers were analyzed. Plasma and cellular methylglyoxal (MG) levels, as well as Glyoxalase 1 (GLO1) enzyme activity and protein expression, were measured in WT and Trpc1/4/5/6

resultsWe find that Trpc1/4/5/6

conclusionThe protective phenotype in diabetic retinopathy observed in Trpc1/4/5/6

Indexed as

AnimalsCells, CulturedDiabetic RetinopathyFemaleLactoylglutathione LyaseMaleMiceMice, Inbred C57BLPyruvaldehydeRetinaTRPC Cation ChannelsGlo1 protein, mouseLactoylglutathione LyasePyruvaldehydeTRPC Cation ChannelsDiabetic retinopathyGlyoxalase1MethylGlyoxalReactive metabolitesTRPC cation channelsVasoregression

Identifiers

PMID29373286
PMCPMC5870093
OpenAlexW2782168921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.