Evidence map›Paper›PMID 29373198›Full record

ReviewCytokine & growth factor reviews2018

Lineage specification in innate lymphocytes.

Arundhoti Das, Christelle Harly, Qi Yang, Avinash Bhandoola

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Regulation of innate lymphoid cell by microbial metabolites.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  4. Article
  5. Review
  6. ILC Differentiation from Progenitors in the Bone Marrow.Advances in experimental medicine and biology · 2022
    Review
  7. The Role of Innate Lymphoid Cells in Cancer Development and Immunotherapy.Frontiers in cell and developmental biology · 2022
    Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Arundhoti DasLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Christelle HarlyLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Qi YangDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, 12208, USA.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: avinash.bhandoola@nih.gov.
Center for Cancer Research · USAlbany Medical Center Hospital · USNational Cancer Institute · US

Funding

T cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5M
Innate Lymphoid Cell AgingR01AG057782 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI YANG, QI · 2017 to 2021
$1.7M
Early Innate Lymphoid Cell DevelopmentK22AI116728 · NIAID · ALBANY MEDICAL COLLEGE · PI YANG, QI · 2016 to 2017
$269k
NIAID NIH HHS K22 AI116728NIA NIH HHS R01 AG057782
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are immune cells that lack specific antigen receptors but possess similar effector functions as T cells. Concordantly, ILCs express many transcription factors known to be important for T cell effector function. ILCs develop from lymphoid progenitors in fetal liver and adult bone marrow. However, the identification of ILC progenitor (ILCP) and other precursors in peripheral tissues raises the question of whether ILC development might occur at extramedullary sites. We discuss central and local generation in maintaining ILC abundance at peripheral sites.

Indexed as

AnimalsBone Marrow CellsHumansImmunity, InnateLymphocytesT-LymphocytesTranscription FactorsTranscription FactorsCentral progenitorsDevelopmentHomingILC distributionInnate lymphoid cellsPeripheral ILC generation

Identifiers

PMID29373198
PMCPMC6043410
OpenAlexW2784020526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.