Evidence map›Paper›PMID 29373141›Full record

ArticleBrazilian journal of anesthesiology (Elsevier)

[The influence of the menstrual cycle on acute and persistent pain after laparoscopic cholecystectomy].

Sinem Sari, Betul Kozanhan, Ayse Ilksen Egilmez, Aykut Soyder, Osman Nuri Aydin, Fabrizio Galimberti, Daniel Sessler, Alparslan Turan

Open access · diamondAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Sinem SariAdnan Menderes University Medical Faculty, Department of Anesthesiology and Reanimation, Aydin, Turquia.
Betul KozanhanUniversity of Health Sciences, Konya Education and Research Hospital, Department of Anesthesiology and Reanimation, Konya, Turquia. Electronic address: betulkozanhan@gmail.com.
Ayse Ilksen EgilmezUniversity of Health Sciences, Konya Education and Research Hospital, Department of Anesthesiology and Reanimation, Konya, Turquia.
Aykut SoyderAdnan Menderes University Medical Faculty, Department of General Surgery, Aydin, Turquia.
Osman Nuri AydinAdnan Menderes University Medical Faculty, Department of Anesthesiology and Reanimation, Aydin, Turquia.
Fabrizio GalimbertiCleveland Clinic Lerner College of Medicine, Cleveland, OH, Estados Unidos da América.
Daniel SesslerCleveland Clinic, Department of Outcomes Research, Cleveland, OH, Estados Unidos da América.
Alparslan TuranCleveland Clinic, Department of Outcomes Research, Cleveland, OH, Estados Unidos da América.
Adnan Menderes University · TRCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USKonya Food and Agriculture University · TRSağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesFluctuations of female sex hormones during menstrual cycle influence pain perception. Endogenous pain inhibition is impaired in follicular phase of menstrual cycle. We tested the primary hypothesis that the women having surgery during their follicular phase have more acute pain and require higher opioids than those in the luteal phase, and secondarily we tested that women who have surgery during their follicular phase have more incisional pain at 3 month postoperatively.

methods127 adult females having laparoscopic cholecystectomy were randomized to have surgery during the luteal or follicular phase of their menstrual cycle. Standardized anesthesia and pain management regimen was given to all patients. Pain and analgesic consumption were evaluated in post-anesthesia care unit and every 4h in the first 24h. Adverse effects were questioned every 4h. Time to oral intake and ambulation were recorded. Post-surgical pain, hospital anxiety, depression scale, SF-12 questionnaire were evaluated at 1 and 3 month visits.

resultsThere was no difference in acute pain scores and analgesic consumption through the 24h period, Visual Analog Scale at 24h was 1.5±1.5cm for follicular group 1.4±1.7cm for luteal group (p=0.57). Persistent postoperative pain was significantly more common one and at three month, with an incidence was 33% and 32% in the patients at follicular phase versus 16% and 12% at luteal phase, respectively. The Visual Analog Scale at one and at three month was 1.6±0.7cm and 1.8±0.8cm for follicular group and 2.7±1.3cm and 2.9±1.7cm in the luteal group (p=0.02), respectively. There were no significant differences between the groups with respect to anxiety and depression, SF-12 scores at either time. Nausea was more common in follicular-phase group (p=0.01) and oral feeding time was shorter in follicular phase (5.9±0.9h) than in luteal phase (6.8±1.9h, p=0.02).

conclusionsAlthough persistent postoperative pain was significantly more common one and three months after surgery the magnitude of the pain was low. Our results do not support scheduling operations to target particular phases of the menstrual cycle.

Indexed as

Acute painCholecystectomyChronic painCiclo menstrualColecistectomiaDor agudaDor crônicaDor pós‐operatóriaLaparoscopiaLaparoscopyMenstrual cyclePostoperative pain

Identifiers

PMID29373141
PMCPMC9391774
OpenAlexW2773635820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.