Evidence map›Paper›PMID 29373038›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia.

Laura Weise-Cross, Michelle A Sands, Joshua R Sheak, Brad R S Broughton, Jessica B Snow, Laura V Gonzalez Bosc, Nikki L Jernigan, Benjimen R Walker, Thomas C Resta

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Mechanisms Underlying Altitude-Induced and Group 3 Pulmonary Hypertension.International journal of molecular sciences · 2026
    Review
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  12. American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
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  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Laura Weise-CrossVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Michelle A SandsVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Joshua R SheakVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.ORCID 0000-0002-8002-4365
Brad R S BroughtonVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Jessica B SnowVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Laura V Gonzalez BoscVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Nikki L JerniganVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Benjimen R WalkerVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Thomas C RestaVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
University of New Mexico · US

Funding

FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (T32)T32HL007736 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 1993 to 2025
$6.5M
Pulmonary Vasoreactivity Following Chronic HypoxiaR01HL088192 · NHLBI · UNIVERSITY OF NEW MEXICO · PI RESTA, THOMAS C · 2008 to 2012
$1.9M
Vascular Smooth Muscle Signaling in Intermittent Hypoxia-Induced Pulmonary HypertensionR01HL132883 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL088192NHLBI NIH HHS R01 HL132883NHLBI NIH HHS T32 HL007736NIGMS NIH HHS K12 GM088021
6 · The paper itself

Abstract

Chronic hypoxia (CH) augments basal and endothelin-1 (ET-1)-induced pulmonary vasoconstrictor reactivity through reactive oxygen species (ROS) generation and RhoA/Rho kinase (ROCK)-dependent myofilament Ca

Indexed as

Vascular RemodelingVasoconstrictionActin CytoskeletonActin Depolymerizing FactorsActinsAnimalsChronic DiseaseDisease Models, AnimalEndothelin-1Hypertension, PulmonaryHypoxiaMaleOxidative StressPhosphorylationPolymerizationPulmonary ArteryActin Depolymerizing FactorsActinsEndothelin-1RhoA protein, ratrho-Associated Kinasesrho GTP-Binding ProteinsVasoconstrictor Agentsactin polymerizationchronic hypoxiapulmonary hypertensionreactive oxygen speciesRho kinase

Identifiers

PMID29373038
PMCPMC6008138
OpenAlexW2785094744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.