Evidence map›Paper›PMID 29373036›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.

Pavel Zhabyeyev, Subhash K Das, Ratnadeep Basu, Mengcheng Shen, Vaibhav B Patel, Zamaneh Kassiri, Gavin Y Oudit

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Multifaceted roles of neutrophils in cardiac disease.Journal of leukocyte biology · 2025
    Review
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  5. Carnitine-acylcarnitine translocase deficiency caused byThe Journal of international medical research · 2023
    Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pavel ZhabyeyevDivision of Cardiology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada.
Subhash K DasDivision of Cardiology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada.
Ratnadeep BasuDivision of Cardiology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada.
Mengcheng ShenDepartment of Physiology, University of Alberta , Edmonton, Alberta , Canada.
Vaibhav B PatelDivision of Cardiology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada.
Zamaneh KassiriMazankowski Alberta Heart Institute, University of Alberta , Edmonton, Alberta , Canada.
Gavin Y OuditDivision of Cardiology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3

Indexed as

AnimalsCardiomyopathiesCation Transport ProteinsCytokinesDisease Models, AnimalFerroportinFibrosisInflammation MediatorsIron OverloadLiverLiver DiseasesMaleMatrix MetalloproteinasesMice, Inbred C57BLMice, KnockoutMyocardiumCation Transport ProteinsCytokinesFerroportinInflammation MediatorsMatrix MetalloproteinasesTissue Inhibitor of Metalloproteinase-3cardiomyopathyheart diseaseiron overloadliver diseasetissue inhibitor of metalloproteinase 3

Identifiers

PMID29373036
PMCPMC6008152
OpenAlexW2785003201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.