Evidence map›Paper›PMID 29372649›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers.

Cintia Chamorro-Petronacci, Mario Perez-Sayáns, Maria Elena Padín-Iruegas, Xabier Marichalar-Mendia, Mercedes Gallas-Torreira, Abel García García

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cintia Chamorro-Petronaccia Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry , Instituto de Investigación Sanitaria de Santiago (IDIS) , Santiago de Compostela , Spain.ORCID http://orcid.org/0000-0002-5637-9908
Mario Perez-Sayánsa Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry , Instituto de Investigación Sanitaria de Santiago (IDIS) , Santiago de Compostela , Spain.ORCID http://orcid.org/0000-0003-2196-9868
Maria Elena Padín-Iruegasb Anatomy and Human Embryology, Functional Biology and Health Science Department , Vigo University , Vigo , Spain.ORCID http://orcid.org/0000-0002-9302-7768
Xabier Marichalar-Mendiac Faculty of Medicine and Dentistry, Stomatology Department , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea , Bilbao , Spain.ORCID http://orcid.org/0000-0001-5948-9443
Mercedes Gallas-Torreiraa Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry , Instituto de Investigación Sanitaria de Santiago (IDIS) , Santiago de Compostela , Spain.ORCID http://orcid.org/0000-0003-4625-3321
Abel García Garcíaa Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry , Instituto de Investigación Sanitaria de Santiago (IDIS) , Santiago de Compostela , Spain.ORCID http://orcid.org/0000-0002-5911-5537
Instituto de Investigación Sanitaria de Santiago · ESUniversidade de Vigo · ESUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall nucleolar RNAs (snoRNAs) are small non-coding RNA sequences whose most studied function is ribosome biogenesis. The altered expression of snoRNA is observed in tumoral processes such as breast cancer and multiple myeloma. However, we have not found any references to snoRNAs in oral squamous cell carcinomas (OSCC) in the literature at the time this article was written. MATERIAL AND

methodsWe have analyzed snoRNA expression in frozen OSCC tissue samples and have compared them to healthy controls. RNA was extracted from a total of eight OSCC samples and eight control samples, measuring the differential expression of small RNAs with the Affymetrix

resultsResults were analyzed using the Transcriptome Analysis Console 3.0 (TAC) software. We obtained a total of 16 deregulated snoRNAs of which one was over expressed and 15 were under expressed. SnoRNAs expression was altered in OSCC and could serve as a diagnostic marker.

Indexed as

AdolescentAdultAgedBiomarkers, TumorCarcinoma, Squamous CellFemaleGene ExpressionHumansMaleMiddle AgedMouth NeoplasmsOligonucleotide Array Sequence AnalysisRibonucleoproteins, Small NucleolarYoung AdultBiomarkers, TumorRibonucleoproteins, Small NucleolarepigeneticsOral cancersnoRNA

Identifiers

PMID29372649
PMCPMC6010090
OpenAlexW2790251639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.