Evidence map›Paper›PMID 29372537›Full record

ReviewClinical reviews in allergy & immunology2019

Sex and Management of Rheumatoid Arthritis.

Ennio Giulio Favalli, Martina Biggioggero, Chiara Crotti, Andrea Becciolini, Maria Gabriella Raimondo, Pier Luigi Meroni

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06337370 (Self-management Nursing Intervention for Women With Rheumatoid Arthritis), which is not on this map. Cited by 112 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 5 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06337370 nacompletednot on this mapstarted 2024, after this paper: background citation

Self-management Nursing Intervention for Women With Rheumatoid Arthritis: A Pragmatic Randomized Clinical Trial

TypeinterventionalSponsorUniversidad Nacional de ColombiaRan2024 to 2025Enrolled44ConditionsArthritis, RheumatoidArmsChronic Disease Self Management Program, Conventional Intervention- Standard care
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 5 syntheses or guidelines pooled it, 247 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ennio Giulio FavalliDepartment of Rheumatology, Gaetano Pini Institute, Via Gaetano Pini, 9, 20122, Milan, Italy. ennio.favalli@gmail.com.
Martina BiggioggeroDepartment of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy.
Chiara CrottiDepartment of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy.
Andrea BeccioliniDepartment of Rheumatology, Gaetano Pini Institute, Via Gaetano Pini, 9, 20122, Milan, Italy.
Maria Gabriella RaimondoDepartment of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy.
Pier Luigi MeroniDepartment of Clinical Sciences and Community Health, University of Milan and IRCCS Istituto Auxologico Italiano, Milan, Italy.
Istituto Ortopedico Gaetano Pini · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease more common in women than men (3:1). Although sex-based differences may play a complex role in promoting an autoimmune dysfunction, to date the comprehensive knowledge of the link between sex and RA is still partially lacking. Furthermore, males and females have been demonstrated to differently deal with their chronic pathologies, modifying the perceived sex-based burden of disease. Gender medicine is a newly approach focusing on the impact of gender differences on human physiology, pathophysiology, and clinical features of diseases, analyzing the complex interrelation and integration of sex and psychological and cultural behavior. A better comprehension of possible factors influencing sexual dimorphism in RA susceptibility, pattern of presentation, disease activity, and outcome could contribute to a tailored approach, in order to limit the morbidity of the disease. RA disease activity seems to be higher in women, whereas the response rate to synthetic and biologic disease-modifying therapies appears to be better in males. Moreover, the common strategies for RA management may be affected by concomitant pregnancy or childbearing desire, with particular regard to treatments with potential teratogenic effects or impact on fertility. Finally, comorbidities, such as fibromyalgia, major depression, and osteoporosis, are more frequent in females, while the impact of sex on cardiovascular risk is still controversial. Moving from the role of sex in influencing RA pathogenesis, epidemiology, and disease characteristics, this review explores the evidence on how sex can have an impact on strategies for managing patients with RA.

Indexed as

AdultAgedAntirheumatic AgentsArthritis, RheumatoidBiological ProductsCardiovascular DiseasesComorbidityDisease ProgressionFemaleFibromyalgiaHumansLactationMaleMiddle AgedOsteoporosisPregnancyAntirheumatic AgentsBiological ProductsGender medicineLactationPregnancyRheumatoid arthritisSexTreatments

Identifiers

PMID29372537
OpenAlexW2785517961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.