Evidence map›Paper›PMID 29372310›Full record

ArticleEuropean journal of nutrition2019

Potential of delphinidin-3-rutinoside extracted from Solanum melongena L. as promoter of osteoblastic MC3T3-E1 function and antagonist of oxidative damage.

Lavinia Casati, Francesca Pagani, Marta Fibiani, Roberto Lo Scalzo, Valeria Sibilia

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In one paragraph

Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Enocyanin promotes osteogenesis and bone regeneration by inhibiting MMP9.International journal of molecular medicine · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Sex Steroid Regulation of Oxidative Stress in Bone Cells: An In Vitro Study.International journal of environmental research and public health · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Comparison of osteogenic differentiation induced byInternational journal of nanomedicine · 2019
    Article
  15. A Polyphenol Rich Extract fromMolecules (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lavinia CasatiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli, 32, 20129, Milano, Italy.ORCID http://orcid.org/0000-0001-9044-6767
Francesca PaganiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli, 32, 20129, Milano, Italy.
Marta FibianiResearch Centre for Engineering and Agro-Food Processing (CREA-IT), Via Venezian 26, 20133, Milano, Italy.
Roberto Lo ScalzoResearch Centre for Engineering and Agro-Food Processing (CREA-IT), Via Venezian 26, 20133, Milano, Italy.
Valeria SibiliaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli, 32, 20129, Milano, Italy. valeria.sibilia@unimi.it.ORCID http://orcid.org/0000-0003-1250-724X
University of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIncreasing evidence suggests the potential use of natural antioxidant compounds in the prevention/treatment of osteoporosis. This study was undertaken to investigate the effects of purified delphinidin-3-rutinoside (D3R), isolated from Solanum melongena L., on osteoblast viability and differentiation in basal conditions and its ability to protect MC3T3-E1 cells against oxidative damage induced by tert-butyl hydroperoxide (t-BHP).

methodsMC3T3-E1 osteoblastic cells were treated with D3R (10

resultsD3R (10

conclusionsThese findings indicate that D3R protects MC3T3-E1 cells from oxidative damage and suggest the potential utility of dietary D3R supplement to prevent osteoblast dysfunction in age-related osteoporosis.

Indexed as

Solanum melongenaAnimalsAnthocyaninsAntioxidantsCell LineCells, CulturedCell SurvivalMiceOsteoblastsOxidative StressPlant ExtractsAnthocyaninsAntioxidantsdelphinidin-3-rutinosidePlant ExtractsDelphinidin-3-rutinosideFunctional food componentOsteoblastic MC3T3-E1 cellsOxidative stress

Identifiers

PMID29372310
OpenAlexW2784742909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.