Evidence map›Paper›PMID 29372145›Full record

ArticleObstetrics & gynecology science2018

Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium.

Joo Young Kim, Wen Hao Wu, Jin Hyun Jun, Jeenah Sohn, Yong Soo Seo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics & gynecology science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joo Young KimDepartment of Obstetrics and Gynecology, Eulji General Hospital, Eulji University, Seoul, Korea.
Wen Hao WuDepartment of Obstetrics and Gynecology, Eulji Medi-Bio Research Institute, Eulji University, Daejeon, Korea.
Jin Hyun JunDepartment of Obstetrics and Gynecology, Eulji Medi-Bio Research Institute, Eulji University, Daejeon, Korea.
Jeenah SohnDepartment of Obstetrics and Gynecology, Eulji General Hospital, Eulji University, Seoul, Korea.
Yong Soo SeoDepartment of Obstetrics and Gynecology, Eulji General Hospital, Eulji University, Seoul, Korea.ORCID https://orcid.org/0000-0001-9404-6138
Eulji University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCorticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy. We investigated regulatory effects of different concentrations of CRH on KATP channel expression in human myometrial smooth muscle cells (HSMCs) in

methodsAfter treating HSMCs with different concentrations of CRH (1, 10, 10

resultsWhen HSMCs were treated with low (1 pmol/L) and high (10

conclusionOur data demonstrated the regulatory effect was different when HSMCs were treated with low (early pregnancy-like) and high (labor-like) CRH concentrations and the KATP channel expression showed significant increase and decrease. This could cause inhibition and activation, respectively, of uterine muscle contraction, demonstrating opposite dual actions of CRH.

Indexed as

Corticotropin-releasing hormoneHuman myometriumKATP channelsPregnancy

Identifiers

PMID29372145
PMCPMC5780309
OpenAlexW2779741546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.