ArticleCancer biology & medicine2017
Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry.
Article in Cancer biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- IRS2 as a driver and therapeutic target in brain metastases from colorectal cancer: a systematic review of mechanistic and translational evidence.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Survival Outcome of Surgical Resection vs. Radiotherapy in Brain Metastasis From Colorectal Cancer: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Brain metastases from colorectal cancer - a retrospective dual center study.Journal of neuro-oncology · 2026Article
- Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes.World journal of gastrointestinal pathophysiology · 2025Article
- Incidence, demographics, and survival of patients with brain metastases from stage IV colorectal cancer: a population-based study from 2013 to 2023.Journal of neuro-oncology · 2025Article
- Surgical excision and radiotherapy for brain metastasis from colorectal cancer: How frailty and comorbidity indices influence outcome.The Kaohsiung journal of medical sciences · 2024Article
- Nomograms for predicting overall survival in colorectal cancer patients with metastasis to the liver, lung, bone, and brain.Cancer causes & control : CCC · 2023Article
- Cetuximab plus XELOX show efficacy against brain metastasis from colorectal cancer: a case report.CNS oncology · 2023Article
- Primary Tumor Resection Provides Survival Benefits for Patients with Synchronous Brain Metastases from Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- Risk Factors on the Incidence and Prognostic Effects of Colorectal Cancer With Brain Metastasis: A SEER-Based Study.Frontiers in oncology · 2022Article
- Review
- Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer.World journal of surgical oncology · 2021Article
- Factors Prognostic for Brain Metastases from Colorectal Cancer: A Single-Center Experience in China.Cancer management and research · 2021Article
- Colorectal Cancer Metastases to Brain or Bone and the Relationship to Primary Tumor Location: a Population-Based Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study.World journal of gastrointestinal oncology · 2020Article
- Clinical, histopathological and immunohistochemical features of brain metastases originating in colorectal cancer: a series of 27 consecutive cases.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBrain metastasis is considered rare in metastatic colorectal cancer (mCRC); thus, surveillance imaging does not routinely include the brain. The reported incidence of brain metastases ranges from 0.6% to 3.2%.
methodsThe South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brain metastasis during their lifetime. Due to small numbers, a descriptive analysis is presented.
resultsOnly 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis (1.4%). The clinical characteristics of those with brain metastasis were as follows: the median age was 65.3 years and 51% were female. Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (
conclusionsBrain metastasis is a rare outcome in advanced CRC. Patients within the registry tended to be female, young in age, and harbored with higher rates of
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