ArticleIranian journal of basic medical sciences2018
Protective effect of metformin on D-galactose-induced aging model in mice.
Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Antioxidant Activity of EthanolicMolecules (Basel, Switzerland) · 2026Article
- A High Dose of Short-term Intraperitoneal D-galactose-induced Aging Process in Male Rats.Annals of African medicine · 2026Article
- Effects ofNarra J · 2025Article
- Effectiveness and mechanisms of combined use of antioxidant nutrients in protecting against oxidative stress-induced neuronal loss and related neurological deficits.CNS neuroscience & therapeutics · 2024Article
- Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice.Journal of medicine and life · 2024Article
- Chelidonic acid abrogates oxidative stress and memory dysfunction in experimental aging rats.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Aging Parameters of the Accelerated Aging Procedure through D-Galactose Induction.Acta medica Philippina · 2024Article
- A Pectic Polysaccharide fromAntioxidants (Basel, Switzerland) · 2023Article
- Distinct signatures on d-galactose-induced aging and preventive/protective potency of two low-dose vitamin D supplementation regimens on working memory, muscular damage, cardiac and cerebral oxidative stress, and SIRT1 and calstabin2 downregulation.Food science & nutrition · 2023Article
- Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis.Pharmacological reports : PR · 2023Review
- Evaluation of Chemical Constituents of Litchi Pericarp Extracts and Its Antioxidant Activity in Mice.Foods (Basel, Switzerland) · 2022Article
- A comparative study of anti-aging effects ofJournal of clinical and translational research · 2022Article
- Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway.Scientific reports · 2022Article
- Neuroprotective effect of low-dose paracetamol treatment against cognitive dysfunction in d-galactose-induced aging mice.Heliyon · 2022Article
- We are all aging, and here's why.Aging medicine (Milton (N.S.W)) · 2022Review
- Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions.Aging and disease · 2022Article
- Neurogenesis in aging and age-related neurodegenerative diseases.Ageing research reviews · 2022Review
- Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats.Iranian journal of basic medical sciences · 2022Article
- Atorvastatin modulates the expression of aging-related genes in the brain of aging induced by D-galactose in mice.Iranian journal of basic medical sciences · 2021Article
- Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesMetformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. MATERIALS AND
methodsMet (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF).
resultsMet decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice.
conclusionOur results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.
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