Evidence map›Paper›PMID 29371928›Full record

ArticleOncotarget2017

Differentially expressed mRNAs, lncRNAs, and miRNAs with associated co-expression and ceRNA networks in ankylosing spondylitis.

Chen Zhang, Chen Wang, Zhenyu Jia, Wenwen Tong, Delin Liu, Chongru He, Xuan Huang, Weidong Xu

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chen ZhangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Chen WangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhenyu JiaDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wenwen TongDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Delin LiuDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Chongru HeDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xuan HuangDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Weidong XuDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Second Military Medical University · CNChanghai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by systemic inflammation and pathological osteogenesis. However, the genetic etiology of AS remains largely unknown. This study aimed to explore the potential role of coding and noncoding genes in the genetic mechanism of AS. Using microarray analyses, this study comprehensively compared lncRNA, microRNA, and mRNA profiles in hip joint ligament tissues from patients with AS and controls. A total of 661 lncRNAs, 574 mRNAs, and 22 microRNAs were differentially expressed in patients with AS compared with controls. Twenty-two of these genes were then validated using real-time polymerase chain reaction. Gene ontology and pathway analyses were performed to explore the principal functions of differentially expressed genes. The pathways were involved mainly in immune regulation, intercellular signaling, osteogenic differentiation, protein synthesis, and degradation. Gene signal transduction network, coding-noncoding co-expression network, and competing endogenous RNA expression network were constructed using bioinformatics methods. Then, two

Indexed as

ankylosing spondylitiscompeting endogenous RNAlong noncoding RNAmicroarraymiRNA

Identifiers

PMID29371928
PMCPMC5768345
OpenAlexW2770241723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.