Evidence map›Paper›PMID 29371826›Full record

ArticleReproductive medicine and biology2018

Long-term clinical outcomes of testicular sperm extraction and intracytoplasmic sperm injection for infertile men.

Noriyuki Okuyama, Ryuichiro Obata, Nao Oka, Yusuke Nakamura, Hiromitsu Hattori, Yukiko Nakajo, Nobuya Aono, Masae Koizumi, Mayumi Toya, Koichi Nagao and 4 more

Open access · goldAbstract read
In one paragraph

Article in Reproductive medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  5. 2023 Canadian Urological Association guideline: Evaluation and management of azoospermia.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Noriyuki OkuyamaKyono ART Clinic Takanawa Tokyo Japan.
Ryuichiro ObataKyono ART Clinic Takanawa Tokyo Japan.
Nao OkaKyono ART Clinic Takanawa Tokyo Japan.
Yusuke NakamuraKyono ART Clinic Sendai Japan.
Hiromitsu HattoriKyono ART Clinic Sendai Japan.
Yukiko NakajoKyono ART Clinic Sendai Japan.
Nobuya AonoKyono ART Clinic Takanawa Tokyo Japan.
Masae KoizumiKyono ART Clinic Sendai Japan.
Mayumi ToyaKyono ART Clinic Sendai Japan.
Koichi NagaoFirst Department of Urology Toho University School of Medicine Tokyo Japan.
Toshihiro TaiFirst Department of Urology Toho University School of Medicine Tokyo Japan.
Tomoko HashimotoKyono ART Clinic Takanawa Tokyo Japan.
Hideki IgarashiKyono ART Clinic Takanawa Tokyo Japan.
Koichi KyonoKyono ART Clinic Takanawa Tokyo Japan.ORCID 0000-0001-5298-2964
Musashino Art University · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To find the best methods to achieve the highest pregnancy and birth rates for couples needing testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI). Methods: Retrospectively studied were 801 patients with male factor infertility who had undergone TESE-ICSI between April, 1996 and July, 2016 and who had been categorized into four groups: obstructive azoospermia (OA); non-obstructive azoospermia (NOA); Klinefelter syndrome (KS); and cryptozoospermia (Crypt). The sperm retrieval rate, hormone levels, fertilization rate (FR), pregnancy rate (PR), and birth rate (BR) after ICSI among three groups were compared: fresh testicular sperm (FS)-fresh oocytes (FO) (Group I); frozen-thawed testicular sperm-FO (Group II); and FS-vitrified-warmed oocytes (Group III). Results: The testicular sperm recovery rate was 57.8% (463/801): 89.6% in the Crypt, 97.1% in the OA, 28.9% in the NOA, and 42.2% in the KS groups. The follicle-stimulating hormone levels were significantly higher in the NOA and KS groups and the testosterone levels were significantly lower in the KS group. The FR, PR, and BR were: 65.2%, 43.2%, and 28.5% in group I; 59.2%, 33.4%, and 18.7% in group II; and 56.4%, 33.8%, and 22.1% in group III. Conclusion: Intracytoplasmic sperm injection with FS-FO achieved the best PR and BR. It should be considered what to do in cases with no testicular sperm by TESE. The authors hope that ICSI with donor sperm will be allowed in Japan in the near future.

Indexed as

azoospermiafresh testicular spermfrozen testicular spermintracytoplasmic sperm injectiontesticular sperm extraction

Identifiers

PMID29371826
PMCPMC5768980
OpenAlexW2773875190

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.