Evidence map›Paper›PMID 29371754›Full record

ArticleJournal of clinical biochemistry and nutrition2018

Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats.

Weina Gao, Lingling Pu, Ming Chen, Jingyu Wei, Zhonghao Xin, Yawen Wang, Zhanxin Yao, Tala Shi, Changjiang Guo

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Wolfberry (Antioxidants (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Weina GaoTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Lingling PuTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Ming ChenThe People's Hospital of Lichuan, Jiangxi Province, 344600, P. R. China.
Jingyu WeiTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Zhonghao XinTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Yawen WangTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Zhanxin YaoTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Tala ShiTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
Changjiang GuoTianjin Institute of Health and Environmental Medicine, NO.1 Dali Road, Tianjin 300050, P. R. China.
People's Hospital of Bishan District · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we showed that 0.5% quercetin simultaneously decreased serum homocysteine and glutathione (GSH) levels in rats. The aim of the present study was to investigate the effects of 0.5% quercetin on GSH metabolism, related enzymes and signal pathways in rats. Rats were fed the control diet and 0.5% quercetin-supplemented diet for 6 weeks. The results showed that quercetin reduced serum and hepatic content of GSH and the ratio of GSH and oxidized glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione

Indexed as

glutamate cysteine ligaseglutathioneMAPKsNrf2quercetin

Identifiers

PMID29371754
PMCPMC5773830
OpenAlexW2775058564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.