Evidence map›Paper›PMID 29371676›Full record

ArticleScientific reports2018

Assessment of the characteristics and biocompatibility of gelatin sponge scaffolds prepared by various crosslinking methods.

Gang Yang, Zhenghua Xiao, Haiyan Long, Kunlong Ma, Junpeng Zhang, Xiaomei Ren, Jiang Zhang

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 280 citations in OpenAlex.

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  9. Unraveling the Potential ofBiomacromolecules · 2026
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gang YangDepartment of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, 610065, China. yang_gang@scu.edu.cn.
Zhenghua XiaoDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Haiyan LongCenter of Engineering-Training, Chengdu Aeronautic Polytechnic, Chengdu, 610100, China.
Kunlong MaDepartment of Orthopaedics, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Junpeng ZhangDepartment of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, 610065, China.
Xiaomei RenDepartment of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, 610065, China.
Jiang ZhangDepartment of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, 610065, China. zhangjiang_@hotmail.com.
Chengdu University of Information Technology · CNSichuan University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This comparative study aims to identify a biocompatible and effective crosslinker for preparing gelatin sponges. Glutaraldehyde (GTA), genipin (GP), 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC), and microbial transglutaminase (mTG) were used as crosslinking agents. The physical properties of the prepared samples were characterized, and material degradation was studied in vitro with various proteases and in vivo through subcutaneous implantation of the sponges in rats. Adipose-derived stromal stem cells (ADSCs) were cultured and inoculated onto the scaffolds to compare the cellular biocompatibility of the sponges. Cellular seeding efficiency and digestion time of the sponges were also evaluated. Cellular viability and proliferation in scaffolds were analyzed by fluorescence staining and MTT assay. All the samples exhibited high porosity, good swelling ratio, and hydrolysis properties; however, material strength, hydrolysis, and enzymolytic properties varied among the samples. GTA-sponge and GP-sponge possessed high compressive moduli, and EDC-sponge exhibited fast degradation performance. GTA and GP sponge implants exerted strong in vivo rejections, and the former showed poor cell growth. mTG-sponge exhibited the optimal comprehensive performance, with good porosity, compressive modulus, anti-degradation ability, and good biocompatibility. Hence, mTG-sponge can be used as a scaffold material for tissue engineering applications.

Indexed as

Materials TestingAnimalsBiotransformationCell ProliferationCell SurvivalChemical PhenomenaGelatinHydrogelsProteolysisRatsStem CellsTissue ScaffoldsGelatinHydrogels

Identifiers

PMID29371676
PMCPMC5785510
OpenAlexW2806501916

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.