Evidence map›Paper›PMID 29371638›Full record

ArticleScientific reports2018

Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain.

Upal Roy, Vadym Drozd, Andriy Durygin, Jesse Rodriguez, Paul Barber, Venkata Atluri, Xiaohua Liu, Thomas G Voss, Surendra Saxena, Madhavan Nair

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
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  17. Article
  18. Novel Antiretroviral Therapeutic Strategies for HIV.Molecules (Basel, Switzerland) · 2021
    Review
  19. Nanotechnology-based antiviral therapeutics.Drug delivery and translational research · 2021
    Review
  20. Cerebral Vascular Toxicity of Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Upal RoyDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, Texas, USA. upal.roy@utrgv.edu.
Vadym DrozdCenter for the Study of Matter at Extreme Conditions, Florida International University, Miami, Florida, USA.
Andriy DuryginCenter for the Study of Matter at Extreme Conditions, Florida International University, Miami, Florida, USA.
Jesse RodriguezWilliams College, Williamstown, Massachusetts, USA.ORCID http://orcid.org/0000-0003-1575-5687
Paul BarberDepartment of Immunology, Institute of NeuroImmune Pharmacology, Center for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Venkata AtluriDepartment of Immunology, Institute of NeuroImmune Pharmacology, Center for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.ORCID http://orcid.org/0000-0002-8070-6745
Xiaohua LiuProteomics Core, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Thomas G VossVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Surendra SaxenaCenter for the Study of Matter at Extreme Conditions, Florida International University, Miami, Florida, USA.
Madhavan NairDepartment of Immunology, Institute of NeuroImmune Pharmacology, Center for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Immunodeficiency Virus Type 1 (HIV-1) remains one of the leading causes of death worldwide. Present combination antiretroviral therapy has substantially improved HIV-1 related pathology. However, delivery of therapeutic agents to the HIV reservoir organ like Central nervous system (CNS) remains a major challenge primarily due to the ineffective transmigration of drugs through Blood Brain Barrier (BBB). The recent advent of nanomedicine-based drug delivery has stimulated the development of innovative systems for drug delivery. In this regard, particular focus has been given to nanodiamond due to its natural biocompatibility and non-toxic nature-making it a more efficient drug carrier than other carbon-based materials. Considering its potential and importance, we have characterized unmodified and surface-modified (-COOH and -NH

Indexed as

NanodiamondsAlkynesAnti-HIV AgentsAstrocytesBenzoxazinesCells, CulturedCell SurvivalCyclopropanesDrug CarriersEndothelial CellsHumansMacrophagesNeuronsAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesDrug CarriersefavirenzNanodiamonds

Identifiers

PMID29371638
PMCPMC5785470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.