Evidence map›Paper›PMID 29371515›Full record

ReviewJournal of cardiovascular development and disease2015

Neutron Scattering at the Intersection of Heart Health Science and Biophysics.

Drew Marquardt, Richard J Alsop, Maikel C Rheinstädter, Thad A Harroun

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Drew MarquardtInstitute of Molecular Biosciences, Biophysics Division, University of Graz (NAWI Graz), mbox Graz 8010, Austria. drew.marquardt@uni-graz.at.
Richard J AlsopDepartment of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4M1, Canada. alsoprj@mcmaster.ca.
Maikel C RheinstädterDepartment of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4M1, Canada. rheinstadter@mcmaster.ca.ORCID 0000-0002-0558-7475
Thad A HarrounDepartment of Physics, Brock University, St. Catharines, ON L2S 3A1, Canada. thad.harroun@brocku.ca.ORCID 0000-0001-9816-2590
McMaster University · CABrock University · CAUniversity of Graz · AT

Funding

Austrian Science Fund FWF P 27083
6 · The paper itself

Abstract

There is an urgent quest for improved heart health. Here, we review how neutron radiation can provide insight into the molecular basis of heart health. Lower cholesterol, a daily intake of aspirin and supplemental vitamin E are argued to all improve heart health. However, the mechanisms behind these common regimens, and others, are not entirely understood. It is not clear why a daily intake of aspirin can help some people with heart disease, and the benefits of vitamin E in the treatment of reperfusion injury have been heavily debated. The molecular impact of cholesterol in the body is still a hot topic. Neutron scattering experiments present a unique opportunity for biophysicists attempting to address these problems. We review some recently published studies that are advancing our understanding of how cholesterol, vitamin E and aspirin work at the molecular level, by studying the impact of these molecules on the cell membrane. These insights engage the broader health science community with new ways of thinking about these molecules.

Indexed as

neutron scattering, aspirin, cholesterol, vitamin E, Cardiovascular diseases

Identifiers

PMID29371515
PMCPMC5753099
OpenAlexW1569604692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.