Evidence map›Paper›PMID 29371501›Full record

ReviewJournal of fungi (Basel, Switzerland)2018

Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.

Margherita Bertuzzi, Gemma E Hayes, Uju J Icheoku, Norman van Rhijn, David W Denning, Nir Osherov, Elaine M Bignell

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  5. mBio · 2025
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  19. Concurrent Infection with SARS-CoV-2 andJournal of fungi (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Margherita BertuzziManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, UK. margherita.bertuzzi@manchester.ac.uk.
Gemma E HayesNorthern Devon Healthcare NHS Trust, North Devon District Hospital, Raleigh Park, Barnstaple EX31 4JB, UK. gemmahayes1@nhs.net.
Uju J IcheokuManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, UK. pharmjoyce@gmail.com.
Norman van RhijnManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, UK. norman.vanrhijn@postgrad.manchester.ac.uk.
David W DenningThe National Aspergillosis Centre, Education and Research Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK. ddenning@manchester.ac.uk.
Nir OsherovDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. nosherov@post.tau.ac.il.
Elaine M BignellManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, UK. elaine.bignell@manchester.ac.uk.
University of Manchester · GBManchester University NHS Foundation Trust · GBNorth Devon District Hospital · GBTel Aviv University · IL

Funding

Biotechnology and Biological Sciences Research Council BB/G009619/1Medical Research Council G0501164Medical Research Council MC_PC_15072Medical Research Council MR/L000822/1Medical Research Council MR/M02010X/1Medical Research Council MR/S001824/1Wellcome Trust
6 · The paper itself

Abstract

Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to lung integrity against which the human respiratory mucosa has developed various tolerance and defence strategies. However, respiratory disease and immune dysfunction frequently render the human lung susceptible to fungal diseases, the most common of which are the aspergilloses, a group of syndromes caused by inhaled spores of

Indexed as

airway epithelial cells (AECs)Aspergillus fumigatusepithelial responsesfungal pathogenesisinternalizationmorphotypesrespiratory epitheliumspore uptake

Identifiers

PMID29371501
PMCPMC5872311
OpenAlexW2782834892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.