Evidence map›Paper›PMID 29371415›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2018

Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders.

Ausaf A Bari, Charles B Mikell, Aviva Abosch, Sharona Ben-Haim, Robert J Buchanan, Allen W Burton, Stephen Carcieri, G Rees Cosgrove, Pierre-Francois D'Haese, Zafiris Jeffrey Daskalakis and 33 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Metabolic activity in subcallosal cingulate predicts response to deep brain stimulation for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  6. Article
  7. Journal of neural engineering · 2023
    Article
  8. Article
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  11. Neurons as will and representation.Nature reviews. Neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Ausaf A Bari *Department of Neurosurgery, University of California Los Angeles Medical Center, Los Angeles, California, USA.
Charles B Mikell *Department of Neurosurgery, Stony Brook University Hospital, Stony Brook, New York, USA.ORCID 0000-0002-0701-2325
Aviva AboschDepartment of Neurosurgery, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Sharona Ben-HaimDepartment of Neurosurgery, University of California San Diego Health, La Jolla, California, USA.
Robert J BuchananDepartment of Neurosurgery, Seton Brain and Spine Institute, Austin, Texas, USA.
Allen W BurtonNeuromodulation, Movement Disorders, and Pain, St. Jude-Abbott, Plano, Texas, USA.
Stephen CarcieriNeuromodulation, Boston Scientific Corp, Marlborough, Massachusetts, USA.
G Rees CosgroveDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Pierre-Francois D'HaeseSchool of Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Zafiris Jeffrey DaskalakisDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Emad N EskandarDepartment of Neurosurgery, Albert Einstein College of Medicine, Bronx, NY, USA.
Jason L GerrardDepartment of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.
Wayne K GoodmanDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
Benjamin David GreenbergDepartment of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
Robert E GrossDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Clement HamaniDivision of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
Zelma H T KissDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Peter KonradDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brian H KopellDepartment of Neurosurgery, The Mount Sinai Hospital, New York City, New York, USA.
Lothar KrinkeMedtronic Neuromodulation, Minneapolis, Minnesota, USA.
Jean-Philippe LangevinDepartment of Neurosurgery, University of California Los Angeles Medical Center, Los Angeles, California, USA.
Andres M LozanoDivision of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
Donald MaloneDepartment of Psychiatry and Psychology, Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Helen S MaybergDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Jonathan P MillerDepartment of Neurological Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Parag G PatilDepartment of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
DeLea PeichelNeuromodulation, Movement Disorders, and Pain, St. Jude-Abbott, Plano, Texas, USA.
Erika A PetersenDepartment of Neurosurgery, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.
Ali R RezaiNeurological Institute, Ohio State University, Columbus, Ohio, USA.
R Mark RichardsonDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Patricio Riva-PosseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Tejas SankarDivision of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada.
Jason M SchwalbDepartment of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.
Helen Blair SimpsonDepartment of Psychiatry, Columbia University, NY State Psychiatric Institute, New York, NY.
Konstantin SlavinDepartment of Neurosurgery, University of Illinois College of Medicine, Chicago, Illinois, USA.
Paul H StypulkowskiMedtronic Neuromodulation, Minneapolis, Minnesota, USA.
Tor TostesonDepartmentof Biomedical Data Science, Geisel School of Medicine, Dartmouth University, Hanover, New Hampshire, USA.
Peter WarnkeSection of Neurosurgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA.
Jon T WillieDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Kareem A ZaghloulSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Joseph S NeimatDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky, USA.
Nader PouratianDepartment of Neurosurgery, University of California Los Angeles Medical Center, Los Angeles, California, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
Intramural NIH HHS ZIA NS003144
6 · The paper itself

Abstract

objectiveRefractory psychiatric disease is a major cause of morbidity and mortality worldwide, and there is a great need for new treatments. In the last decade, investigators piloted novel deep brain stimulation (DBS)-based therapies for depression and obsessive-compulsive disorder (OCD). Results from recent pivotal trials of these therapies, however, did not demonstrate the degree of efficacy expected from previous smaller trials. To discuss next steps, neurosurgeons, neurologists, psychiatrists and representatives from industry convened a workshop sponsored by the American Society for Stereotactic and Functional Neurosurgery in Chicago, Illinois, in June of 2016.

designHere we summarise the proceedings of the workshop. Participants discussed a number of issues of importance to the community. First, we discussed how to interpret results from the recent pivotal trials of DBS for OCD and depression. We then reviewed what can be learnt from lesions and closed-loop neurostimulation. Subsequently, representatives from the National Institutes of Health, the Food and Drug Administration and industry discussed their views on neuromodulation for psychiatric disorders. In particular, these third parties discussed their criteria for moving forward with new trials. Finally, we discussed the best way of confirming safety and efficacy of these therapies, including registries and clinical trial design. We close by discussing next steps in the journey to new neuromodulatory therapies for these devastating illnesses.

conclusionInterest and motivation remain strong for deep brain stimulation for psychiatric disease. Progress will require coordinated efforts by all stakeholders.

Indexed as

NeurosurgeryHumansMental DisordersNeurosurgical ProceduresUnited Statesdepressionelectrical stimulationpsychiatrystereotaxic surgery

Identifiers

PMID29371415
PMCPMC7340367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.