Evidence map›Paper›PMID 29371405›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of

Jason Bini, Mika Naganawa, Nabeel Nabulsi, Yiyun Huang, Jim Ropchan, Keunpoong Lim, Soheila Najafzadeh, Kevan C Herold, Gary W Cline, Richard E Carson

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Potential of [Scientific reports · 2021
    Article
  7. Review
  8. Review
  9. Optoacoustic Imaging of Glucagon-like Peptide-1 Receptor with a Near-Infrared Exendin-4 Analog.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  10. PET Imaging of Pancreatic Dopamine DJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jason BiniPET Center, Yale University School of Medicine, New Haven, CT jason.bini@yale.edu.
Mika NaganawaPET Center, Yale University School of Medicine, New Haven, CT.
Nabeel NabulsiPET Center, Yale University School of Medicine, New Haven, CT.
Yiyun HuangPET Center, Yale University School of Medicine, New Haven, CT.
Jim RopchanPET Center, Yale University School of Medicine, New Haven, CT.
Keunpoong LimPET Center, Yale University School of Medicine, New Haven, CT.
Soheila NajafzadehPET Center, Yale University School of Medicine, New Haven, CT.
Kevan C HeroldDepartment of Immunobiology and Internal Medicine, Yale University School of Medicine, New Haven, CT.
Gary W ClineDepartment of Immunobiology and Internal Medicine, Yale University School of Medicine, New Haven, CT.
Richard E CarsonPET Center, Yale University School of Medicine, New Haven, CT.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Imaging pancreatic beta-cells with PET neuroimaging agentsDP3DK104092 · NIDDK · YALE UNIVERSITY · PI CARSON, RICHARD E., CLINE, GARY W · 2014 to 2016
$732k
State-of-the-Art Small Animal PET/CT InstrumentationS10OD010322 · OD · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2013 to 2013
$595k
NCATS NIH HHS UL1 TR000142NIDDK NIH HHS DP3 DK104092NIH HHS S10 OD010322
6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM) is characterized by a loss of β-cells in the islets of Langerhans of the pancreas and subsequent deficient insulin secretion in response to hyperglycemia. Development of an in vivo test to measure β-cell mass (BCM) would greatly enhance the ability to track diabetes therapies. β-cells and neurologic tissues have common cellular receptors and transporters, therefore, we screened brain radioligands for their ability to identify β-cells.

Indexed as

Positron Emission Tomography Computed TomographyAdultAnimalsBrainCase-Control StudiesCell SizeDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansInsulin-Secreting CellsMaleOxazinesPrimatesnaxagolideOxazinesdiabetespancreasPETPHNOβ-cell mass

Identifiers

PMID29371405
PMCPMC6071501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.