Evidence map›Paper›PMID 29371400›Full record

ArticleThe Journal of biological chemistry2018

Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.

Steven Molinarolo, Sora Lee, Lilia Leisle, John D Lueck, Daniele Granata, Vincenzo Carnevale, Christopher A Ahern

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Inhibitory effects of aloperine on voltage-gated NaNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Steven MolinaroloFrom the Department of Molecular Physiology and Biophysics, Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242.
Sora Leethe Weill Cornell Medical College, Cornell University, New York, New York 10065, and.
Lilia Leislethe Weill Cornell Medical College, Cornell University, New York, New York 10065, and.
John D LueckFrom the Department of Molecular Physiology and Biophysics, Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242.
Daniele Granatathe Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania 19122.
Vincenzo Carnevalethe Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania 19122.
Christopher A AhernFrom the Department of Molecular Physiology and Biophysics, Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, christopher-ahern@uiowa.edu.
University of Iowa · USCornell University · USTemple University · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI BOWIE, JAMES U · 2010 to 2017
$31.9M
Photochemical determination of sodium channel voltage-dependent gating and compositionR01GM122420 · NIGMS · UNIVERSITY OF IOWA · PI AHERN, CHRISTOPHER A · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM122420NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

Voltage-gated, sodium ion-selective channels (Na

Indexed as

Amino Acid SequenceAnimalsBacteriaBacterial ProteinsEvolution, MolecularHEK293 CellsHumansModels, MolecularPhylogenyProtein ConformationProtein SubunitsRatsVoltage-Gated Sodium ChannelsXenopusBacterial ProteinsProtein SubunitsVoltage-Gated Sodium Channelsauxiliary subunitsbacterial ion channelsbioinformaticselectrical signallingelectrophysiologymembrane biophysicsprotein evolutionsodium channel

Identifiers

PMID29371400
PMCPMC5892571
OpenAlexW2784680411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.