Evidence map›Paper›PMID 29371319›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines.

Edison Chen, Valeria Lallai, Yasmine Sherafat, Nickolas P Grimes, Anna N Pushkin, J P Fowler, Christie D Fowler

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  4. A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  5. Targeting GPR3 as a novel approach for nicotine cessation therapeutic development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Co-release of GABA and ACh from Medial Olivocochlear Neurons as a Fine Regulatory Mechanism of Cochlear Efferent Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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  14. A sex-specific effect of MFrontiers in molecular neuroscience · 2024
    Article
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  17. Effects of Prenatal Nicotine, THC, or Co-Exposure on Cognitive Behaviors in Adolescent Male and Female Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Edison ChenDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.ORCID 0000-0002-7073-9279
Valeria LallaiDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.ORCID 0000-0002-5674-8988
Yasmine SherafatDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.
Nickolas P GrimesDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.
Anna N PushkinDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.
J P FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.
Christie D FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697 cdfowler@uci.edu.ORCID 0000-0003-2864-2163
University of California, Irvine · US

Funding

UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
Circulating miRNAs and Epigenetic Regulation in Nicotine AddictionDP1DA039658 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2015 to 2019
$2.3M
The Habenulo-Interpeduncular Pathway and NicotineR00DA032543 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2014 to 2016
$741k
The Habenulo-Interpeduncular Pathway and NicotineK99DA032543 · NIDA · SCRIPPS FLORIDA · PI FOWLER, CHRISTIE D · 2012 to 2013
$297k
NIDA NIH HHS DP1 DA039658NIDA NIH HHS K99 DA032543NIDA NIH HHS R00 DA032543NIH HHS U42 OD012210
6 · The paper itself

Abstract

The recent development of transgenic rodent lines expressing cre recombinase in a cell-specific manner, along with advances in engineered viral vectors, has permitted in-depth investigations into circuit function. However, emerging evidence has begun to suggest that genetic modifications may introduce unexpected caveats. In the current studies, we sought to extensively characterize male and female mice from both the ChAT

Indexed as

Choline O-AcetyltransferaseGenetic TechniquesIntegrasesModels, AnimalAnimalsBehavior, AnimalChromosomes, Artificial, BacterialFemaleHippocampusInternal Ribosome Entry SitesLocomotionMaleMiceMice, TransgenicNicotineNicotinic AgonistsCholine O-AcetyltransferaseCre recombinaseIntegrasesInternal Ribosome Entry SitesNicotineNicotinic AgonistsVesicular Acetylcholine Transport Proteinsacetylcholinecholine acetyltransferasecre recombinaseintravenous nicotine self-administrationmicetransgenic

Identifiers

PMID29371319
PMCPMC5830509
OpenAlexW2785044715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.