Evidence map›Paper›PMID 29371289›Full record

ArticleClinical science (London, England : 1979)2018

Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.

Sabrina M Scroggins, Donna A Santillan, Jenna M Lund, Jeremy A Sandgren, Lindsay K Krotz, Wendy S Hamilton, Eric J Devor, Heather A Davis, Gary L Pierce, Katherine N Gibson-Corley and 3 more

Abstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026
    Review
  5. Article
  6. Immune dysregulation in bipolar disorder.Journal of affective disorders · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. The Serotonin-Immune Axis in Preeclampsia.Current hypertension reports · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sabrina M ScrogginsDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A.
Donna A SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A.
Jenna M LundCarver College of Medicine, University of Iowa, Iowa City, IA 52242, U.S.A.
Jeremy A SandgrenCarver College of Medicine, University of Iowa, Iowa City, IA 52242, U.S.A.
Lindsay K KrotzDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A.
Wendy S HamiltonDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A.
Eric J DevorDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A.
Heather A DavisInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52242, U.S.A.
Gary L PierceCenter for Hypertension Research, University of Iowa, Iowa City, IA 52242, U.S.A.
Katherine N Gibson-CorleyDepartment of Pathology, University of Iowa, Iowa City, IA 52242, U.S.A.
Curt D SigmundCenter for Hypertension Research, University of Iowa, Iowa City, IA 52242, U.S.A.
Justin L GrobeCenter for Hypertension Research, University of Iowa, Iowa City, IA 52242, U.S.A. mark-santillan@uiowa.edu justin-grobe@uiowa.edu.
Mark K SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, U.S.A. mark-santillan@uiowa.edu justin-grobe@uiowa.edu.
University of Iowa · US

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7M
University of Iowa Clinical and Translational Science Program (KL2)KL2RR024980 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$4.6M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Central Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionR00HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2012 to 2014
$715k
Central Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionK99HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2010 to 2011
$214k
NCATS NIH HHS U54 TR001356NCRR NIH HHS KL2 RR024980NHLBI NIH HHS K99 HL098276NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R00 HL098276NHLBI NIH HHS R01 HL134850NIAID NIH HHS T32 AI007260NICHD NIH HHS K12 HD000849NICHD NIH HHS L30 HD070302NIGMS NIH HHS T32 GM007337
6 · The paper itself

Abstract

The pathogenesis of preeclampsia (PreE), a hypertensive disorder of pregnancy, involves imbalanced T helper (T

Indexed as

AnimalsArginine VasopressinFemaleHumansMaleMice, Inbred C57BLNeurophysinsPlacentaPre-EclampsiaPregnancyProtein PrecursorsT-LymphocytesVasopressinsArginine VasopressinAVP protein, humanNeurophysinsProtein PrecursorsVasopressinsdendritic cellsimmune responsepreeclampsiaT-cellsvasopressin

Identifiers

PMID29371289
PMCPMC5947858
OpenAlexW2785301454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.