Trial reportBMJ open2018
Women, their Offspring and iMproving lifestyle for Better cardiovascular health of both (WOMB project): a protocol of the follow-up of a multicentre randomised controlled trial.
Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Preconception lifestyle advice for people with infertility.The Cochrane database of systematic reviews · 2021Pooled it
- A preconception lifestyle intervention in women with obesity and cardiovascular health in their children.Pediatric research · 2023Trial
- Trial
- Preconception lifestyle intervention in women with obesity and echocardiographic indices of cardiovascular health in their children.International journal of obesity (2005) · 2022Trial
- Trial
- A lifestyle intervention randomized controlled trial in obese women with infertility improved body composition among those who experienced childhood adversity.Stress and health : journal of the International Society for the Investigation of Stress · 2021Trial
- Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials.Scandinavian journal of psychology · 2019Trial
- Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women.Nutrients · 2019Trial
- Long-term effects of a preconception lifestyle intervention on cardiometabolic health of overweight and obese women.European journal of public health · 2019Trial
- Preconception lifestyle intervention reduces long term energy intake in women with obesity and infertility: a randomised controlled trial.The international journal of behavioral nutrition and physical activity · 2019Trial
- Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3⁻8 Years Earlier.Nutrients · 2018Trial
- A lifestyle intervention improves sexual function of women with obesity and infertility: A 5 year follow-up of a RCT.PloS one · 2018Trial
- Trial
- Obesity-fertility cohort study: protocol for the assessment of children aged 6-12 years and their mothers.BMJ open · 2025Article
- The psychosocial impact of exercise as an intervention for persons living with obesity and female infertility: A rapid scoping review and pilot study.PLOS mental health · 2025Article
- Unraveling Childhood Obesity: A Grounded Theory Approach to Psychological, Social, Parental, and Biological Factors.Children (Basel, Switzerland) · 2024Review
- The Influence of Parental Environmental Exposure and Nutrient Restriction on the Early Life of Offspring Growth in Gambia-A Pilot Study.International journal of environmental research and public health · 2022Article
- The role of PCOS in mental health and sexual function in women with obesity and a history of infertility.Human reproduction open · 2021Article
- Sexual function and pelvic floor activity in women: the role of traumatic events and PTSD symptoms.European journal of psychotraumatology · 2020Article
- Associations between preconception macronutrient intake and birth weight across strata of maternal BMI.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWomen, their Offspring and iMproving lifestyle for Better cardiovascular health of both (WOMB) project is the follow-up of the LIFEstyle study, a randomised controlled trial in obese infertile women, and investigates the effects of a preconception lifestyle intervention on later health of women (WOMB women) and their children (WOMB kids). METHODS AND ANALYSIS: Obese infertile women, aged between 18 and 39 years, were recruited in 23 Dutch fertility clinics between June 2009 and June 2012. The 284 women allocated to the intervention group received a 6-month structured lifestyle programme. The 280 women in the control group received infertility care as usual. 4 to 7 years after inclusion in the trial, all women (n=564) and children conceived during the trial (24 months after randomisation) (n=305 singletons and age 3-5 years) will be approached to participate in this follow-up study (starting in 2015). The main focus of outcome will be cardiovascular health, but the dataset comprises a wide range of physical and mental health measures, diet and physical activity measures, child growth and development measures, biological samples and genetic and epigenetic information. The follow-up assessment consists of three stages that take place between 2016 and 2018, and includes (online) questionnaires, accelerometry and physical and behavioural measurements in a mobile research vehicle. A subsample of 100 women and 100 children are planned for cardiac ultrasound measurements. ETHICS AND DISSEMINATION: The protocol of this follow-up study is approved by the local medical ethics committee (University Medical Centre Groningen). Study findings of the WOMB project will be widely disseminated to the scientific community, healthcare professionals, policy makers, future parents and general public. TRIAL REGISTRATION NUMBER: The original LIFEstyle study is registered at The Netherlands Trial Registry (number 1530).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.