Evidence map›Paper›PMID 29371254›Full record

ArticleAJNR. American journal of neuroradiology2018

Local Glioma Cells Are Associated with Vascular Dysregulation.

S G Bowden, B J A Gill, Z K Englander, C I Horenstein, G Zanazzi, P D Chang, J Samanamud, A Lignelli, J N Bruce, P Canoll and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Benign Glioma.Advances in experimental medicine and biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

S G BowdenFrom the Department of Neurological Surgery (S.G.B.), Oregon Health & Science University, Portland, Oregon.ORCID 0000-0001-6320-210X
B J A GillThe Gabriele Bartoli Brain Tumor Research Laboratory (S.G.B., B.J.A.G., Z.K.E., J.S., J.N.B., P.C.).ORCID 0000-0001-5584-6714
Z K EnglanderThe Gabriele Bartoli Brain Tumor Research Laboratory (S.G.B., B.J.A.G., Z.K.E., J.S., J.N.B., P.C.).ORCID 0000-0001-8544-7490
C I HorensteinDepartment of Radiology (C.I.H.), North Shore University Hospital, Long Island, New York.ORCID 0000-0002-8818-3619
G ZanazziPathology and Cell Biology (G.Z., P.C.).ORCID 0000-0001-9606-9501
P D ChangDepartment of Radiology (P.D.C.), University of California, San Francisco, California.ORCID 0000-0002-2675-9483
J SamanamudThe Gabriele Bartoli Brain Tumor Research Laboratory (S.G.B., B.J.A.G., Z.K.E., J.S., J.N.B., P.C.).ORCID 0000-0003-2436-7539
A LignelliRadiology (A.L., J.G.), Columbia University Medical Center, New York, New York.ORCID 0000-0003-2908-9179
J N BruceThe Gabriele Bartoli Brain Tumor Research Laboratory (S.G.B., B.J.A.G., Z.K.E., J.S., J.N.B., P.C.).ORCID 0000-0002-6844-0286
P CanollThe Gabriele Bartoli Brain Tumor Research Laboratory (S.G.B., B.J.A.G., Z.K.E., J.S., J.N.B., P.C.).ORCID 0000-0002-7001-0226
J GrinbandRadiology (A.L., J.G.), Columbia University Medical Center, New York, New York jackgrinband@gmail.com.ORCID 0000-0001-7658-6755
Neurological Surgery · USColumbia University Irving Medical Center · USCell Medica (Switzerland) · CHJisc · GBNorth Shore University Hospital · USOregon Health & Science University · USUniversity of California, San Francisco · US

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

background and purposeMalignant glioma is a highly infiltrative malignancy that causes variable disruptions to the structure and function of the cerebrovasculature. While many of these structural disruptions have known correlative histopathologic alterations, the mechanisms underlying vascular dysfunction identified by resting-state blood oxygen level-dependent imaging are not yet known. The purpose of this study was to characterize the alterations that correlate with a blood oxygen level-dependent biomarker of vascular dysregulation. MATERIALS AND

methodsThirty-two stereotactically localized biopsies were obtained from contrast-enhancing (

resultsBiopsies corresponded to a range of blood oxygen level-dependent signals, ranging from relatively normal (

conclusionsThe relationship between local, neoplastic characteristics and a blood oxygen level-dependent biomarker of vascular function suggests that local effects of glioma cell infiltration contribute to vascular dysregulation.

Indexed as

AdultBrain NeoplasmsFemaleGliomaHumansMagnetic Resonance ImagingMaleMiddle AgedOxygenOxygen

Identifiers

PMID29371254
PMCPMC6060022
OpenAlexW2784793309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.