Evidence map›Paper›PMID 29371236›Full record

ArticleThe Journal of endocrinology2018

CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling.

Sung Wook Park, Shawna D Persaud, Stanislas Ogokeh, Tatyana A Meyers, DeWayne Townsend, Li-Na Wei

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Retinoic acid signaling and metabolism in heart failure.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  4. The ARCNature communications · 2025
    Article
  5. Article
  6. CRABP1-complexes in exosome secretion.Cell communication and signaling : CCS · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Role of cellular retinol-binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi-omic approach.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  20. Synthetic Retinoids Beyond Cancer Therapy.Annual review of pharmacology and toxicology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sung Wook ParkDepartment of PharmacologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Shawna D PersaudDepartment of PharmacologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Stanislas OgokehDepartment of PharmacologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Tatyana A MeyersDepartment of Integrative Biology and PhysiologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
DeWayne TownsendDepartment of Integrative Biology and PhysiologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.
Li-Na WeiDepartment of PharmacologyUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA weixx009@umn.edu.
University of Minnesota Medical Center · US

Funding

Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathwaysR01DK060521 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 2002 to 2022
$6.9M
TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYSR01DK054733 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 1999 to 2021
$5.7M
NIDDK NIH HHS R01 DK054733NIDDK NIH HHS R01 DK060521
6 · The paper itself

Abstract

Excessive and/or persistent activation of calcium-calmodulin protein kinase II (CaMKII) is detrimental in acute and chronic cardiac injury. However, intrinsic regulators of CaMKII activity are poorly understood. We find that cellular retinoic acid-binding protein 1 (CRABP1) directly interacts with CaMKII and uncover a functional role for CRABP1 in regulating CaMKII activation. We generated

Indexed as

AnimalsApoptosisCalcium-Calmodulin-Dependent Protein Kinase Type 2CardiomegalyCardiotonic AgentsEnzyme ActivationHeartIsoproterenolMaleMiceMice, Inbred C57BLMice, KnockoutMyocardiumNecrosisReceptors, Retinoic AcidVentricular RemodelingCalcium-Calmodulin-Dependent Protein Kinase Type 2Cardiotonic AgentsIsoproterenolReceptors, Retinoic Acidretinoic acid binding protein I, cellularCaMKIIcardiac remodelingCRABP1heart failure

Identifiers

PMID29371236
PMCPMC5815894
OpenAlexW2793200565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.