Evidence map›Paper›PMID 29371200›Full record

Observational studyJournal of the American Heart Association2018

Lipid Testing and Statin Dosing After Acute Myocardial Infarction.

William T Wang, Anne Hellkamp, Jacob A Doll, Laine Thomas, Ann Marie Navar, Gregg C Fonarow, Howard M Julien, Eric D Peterson, Tracy Y Wang

2 registry-linked trialsOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06388668 recruitingnot on this mapstarted 2024, after this paper: background citation

Timing of Lipid Testing During Hospitalization for MI and Subsequent Management of Dyslipidemia An Observational Study to Reduce the Care Gaps in Dyslipidemia in Canada

TypeobservationalSponsorMontreal Heart InstituteRan2024 to 2026Enrolled100ConditionsDyslipidemias, Lipid Testing, Myocardial InfarctionArmsLipid panel
NCT06471036 narecruitingnot on this mapstarted 2024, after this paper: background citation

Test 2 Treat: A Randomized Implementation Trial to Improve LDL-C Management After Hospitalization for ASCVD (Atherosclerotic Cardiovascular Disease)

TypeinterventionalSponsorDuke UniversityRan2024 to 2027Enrolled400ConditionsASCVD, LDL-CArmsCare Champion Intervention
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  10. An Expert Opinion on the Role of the Rosuvastatin/Amlodipine Single Pill Fixed Dose Combination in Cardiovascular Prevention.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
  11. Initial statin dose after myocardial infarction and long-term cardiovascular outcomes.European heart journal. Cardiovascular pharmacotherapy · 2023
    Article
  12. Article
  13. High-Intensity Statin Use Among Patients With Atherosclerosis in the U.S.Journal of the American College of Cardiology · 2022
    Article
  14. Article
  15. Quality care in ST-segment elevation myocardial infarction.Journal of the Chinese Medical Association : JCMA · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

William T WangDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Anne HellkampDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Jacob A DollVeterans Affairs Puget Sound Health Care System and the Department of Medicine, University of Washington, Seattle, WA.
Laine ThomasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Ann Marie NavarDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Gregg C FonarowDepartment of Medicine, University of California at Los Angeles Medical Center, Los Angeles, CA.
Howard M JulienDivision of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Eric D PetersonDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Tracy Y WangDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC tracy.wang@duke.edu.
Duke University · USClinical Research Institute · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · USVA Puget Sound Health Care System · US

Funding

Using Data to Drive Change in National CV Care: The Duke CERTSU19HS021092 · AHRQ · DUKE UNIVERSITY · PI PETERSON, ERIC DAVID · 2011 to 2015
$4.2M
AHRQ HHS U19 HS021092
6 · The paper itself

Abstract

backgroundThe 2013 American College of Cardiology/American Heart Association cholesterol guidelines recommend high-intensity statins for patients after myocardial infarction (MI) rather than treating to a low-density lipoprotein cholesterol goal, as the previous ATP III (Adult Treatment Panel third report) guidelines had advised. METHODS AND

resultsTo evaluate the frequency of postdischarge lipid testing and high-intensity statin use among MI patients discharged on a statin during the ATP III guidelines era, we linked ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry data to Medicare claims for 11 046 MI patients aged ≥65 years who were discharged alive on a statin from 347 hospitals (2007-2009). Multivariable regression was used to evaluate the association between lipid testing and 1-year high-intensity statin use. Only 21% of MI patients were discharged on a high-intensity statin. By 90 days after MI, 44% of patients discharged on a statin underwent lipid testing (43% on low- or moderate-intensity statins and 49% on high-intensity statins;

conclusionsPrevious guidelines recommended low-density lipoprotein cholesterol goal-directed statin therapy, but lipid testing and high-intensity statin use were infrequent after MI. The American College of Cardiology/American Heart Association guidelines may promote more intensive cardiovascular risk reduction by eliminating treatment dependence on lipid testing.

Indexed as

AgedAged, 80 and overBiomarkersDatabases, FactualDyslipidemiasFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsMaleMedicareMyocardial InfarctionPractice Guidelines as TopicPredictive Value of TestsRecurrenceRegistriesBiomarkersHydroxymethylglutaryl-CoA Reductase InhibitorsLipidslipid testingmyocardial infarctionstatin dosing

Identifiers

PMID29371200
PMCPMC5850230
OpenAlexW2790530705

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.