Evidence map›Paper›PMID 29371134›Full record

ReviewJournal of molecular and cellular cardiology2018

Pericytes constrict blood vessels after myocardial ischemia.

Matheus A Costa, Ana E Paiva, Julia P Andreotti, Marcus V Cardoso, Carlos D Cardoso, Akiva Mintz, Alexander Birbrair

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022
    Review
  9. Article
  10. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  11. Article
  12. Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patients.International journal of cardiology and cardiovascular diseases · 2021
    Article
  13. Article
  14. Review
  15. Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019
    Review
  16. Staphylococcus epidermidis role in the skin microenvironment.Journal of cellular and molecular medicine · 2019
    Article
  17. Pericyte Plasticity in the Brain.Neuroscience bulletin · 2019
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matheus A CostaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Ana E PaivaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Julia P AndreottiDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Marcus V CardosoDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Carlos D CardosoDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address: birbrair@icb.ufmg.br.

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072
6 · The paper itself

Abstract

No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) by using state-of-the-art technologies, including high-resolution confocal imaging in combination with myocardial ischemia/reperfusion mouse model, reveal that pericytes contribute to the no-reflow phenomenon post-ischemia in the heart. Strikingly, intravenous adenosine increased vascular diameter at pericyte site after cardiac ischemia. This study provides a novel therapeutic target to inhibit no-reflow phenomenon after myocardial ischemia.

Indexed as

VasoconstrictionAnimalsDisease Models, AnimalHumansMyocardial IschemiaPericytesHeartIschemiaPericytesVasoconstriction

Identifiers

PMID29371134
PMCPMC6089363

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.